Abstract: Objective To explore the expression profiles of Lumican in invasive and metastatic endometrial carcinoma. Methods Forty-eight cases of endometrial carcinoma and paired normal endometrium tissues were applied for detecting the expression of Lumican. The mRNA and protein expression profiles of Lumican were analysed by RT-PCR and Western blot, respectively. SPSS13.0 statistical software was adopted to analyze the expression difference of Lumican in endometrial carcinoma. Results Compared with the normal endometrium tissues, mRNA and protein expression of Lumican were down-regulated in endometrial carcinoma tissues （0.54±0.042）vs. (0.87±0.035)；(0.42±0.026) vs. (0.83±0.037）, respectively (P＜0.05). It was showed evidently difference of Lumican expression in 48 cases of endometrial carcinoma, including superficial invasive group (22 cases), deep invasive group (11 cases) /cervix invasive group (11 cases) and lymph metastatic group (4 cases). Conclusion Lumican was downregulated in endometrial carcinoma, Lumican expression was negatively related to the invasion and metastasis of endometrial carcinoma. Low expression of Lumican may be involved in the malignant biological behavior of invasion and metastasis in the endometrial carcinoma.