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三阴性乳腺癌和非三阴性乳腺癌临床特征及预后的比较分析

高炳玉, 刘 玉, 夏立平, 郑武平

高炳玉, 刘 玉, 夏立平, 郑武平. 三阴性乳腺癌和非三阴性乳腺癌临床特征及预后的比较分析[J]. 肿瘤防治研究, 2013, 40(08): 786-788. DOI: 10.3971/j.issn.1000-8578.2013.08.014
引用本文: 高炳玉, 刘 玉, 夏立平, 郑武平. 三阴性乳腺癌和非三阴性乳腺癌临床特征及预后的比较分析[J]. 肿瘤防治研究, 2013, 40(08): 786-788. DOI: 10.3971/j.issn.1000-8578.2013.08.014
GAO Bingyu, LIU Yu, XIA Liping, ZHENG Wuping. Clinical Characteristics and Prognosis A Comparative Study between Triple-negative and Non-triple-negative Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(08): 786-788. DOI: 10.3971/j.issn.1000-8578.2013.08.014
Citation: GAO Bingyu, LIU Yu, XIA Liping, ZHENG Wuping. Clinical Characteristics and Prognosis A Comparative Study between Triple-negative and Non-triple-negative Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(08): 786-788. DOI: 10.3971/j.issn.1000-8578.2013.08.014

三阴性乳腺癌和非三阴性乳腺癌临床特征及预后的比较分析

详细信息
    作者简介:

    高炳玉(1976-),男,本科, 副主任医师,主要从事乳腺与胸部肿瘤研究

    通讯作者:

    刘玉,E-mail:Iamliuyu@tom.com

  • 中图分类号: R737.9;R730.7

Clinical Characteristics and Prognosis A Comparative Study between Triple-negative and Non-triple-negative Breast Cancer

  • 摘要: 目的 比较三阴性乳腺癌和非三阴性乳腺癌临床特征及预后。 方法 对我院2003年-2010年期间住院治疗的560例乳腺癌患者临床资料进行回顾性分析。比较三阴乳腺癌及非三阴乳腺癌的3年、5年生存率及临床特征的差别。 结果 三阴乳腺癌患者的3年生存率及5年生存率为85.5%和73.3%,显著低于非三阴乳腺癌患者(95.1%和88.0%,P<0.05);三阴乳腺癌患者复发率和远行转移率显著高于对照组(P<0.05);三阴乳腺癌患者发病年龄较轻,肿瘤体积较大,与非三阴乳腺癌患者相比差异有统计学意义(P<0.05);Cox多因素分析结果显示:是否为三阴性、肿瘤大小是影响患者预后的独立影响因素。 结论 三阴性乳腺癌有独特的临床病理特征,易发生复发及转移,预后差。

     

    Abstract: Objective To compare the clinical characteristics and prognosis between triple-negative (TNBC) and non-triple-negative breast cancer (NTNBC). Methods From 2003 to 2010, 560 hospitalized invasive breast cancer patients were retrospectively analyzed. 3 year, 5 year survival rate and clinical characteristics were compared between TNBC and NTNBC. Results In patients with TNBC, 3- and 5-year survival rate were 85.5% and 73.3%, respectively. Which were significantly lower than that in NTNBC patients (95.1% and 88.0%, P<0.05). Recurrence and metastasis rate of TNBC patients were significantly higher than that in control group (P<0.05). Compared with NTNBC patients, TNBC patients were with a younger age at onset and larger tumor size (P<0.05). Cox multivariate analysis showed that TNBC and tumor size were independent prognostic factors. Conclusion TNBC has unique clinical characteristics. It tends to recurrence and metastasis, leading to a poor prognosis.

     

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出版历程
  • 收稿日期:  2013-04-06
  • 修回日期:  2013-04-24
  • 刊出日期:  2013-08-24

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