Relationship between Expression of Adiponectin Receptors and Prognosis of Chemotherapy in Colon Cancer after Radical Resection
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摘要: 目的 探讨脂联素受体（AdipoR）在结肠癌组织中的表达及与术后辅助化疗预后的关系。方法 100例结肠癌患者中68例Ⅱ、Ⅲ期术后均予FOLFOX4方案治疗，疗程为8~10周期，随访2年。采用免疫组织化学SP法检测100例结肠癌患者肿瘤组织中脂联素受体的表达情况。 结果 脂联素受体（AdipoR1、AdipoR2）在Dukes分期、肿瘤的病理学分期及有无淋巴结转移间的比较，差异具有统计学意义（P＜0.05）。Kaplan-Meier生存曲线显示：脂联素受体阳性表达者优于阴性表达者，差异具有统计学意义（P＜0.01）；Cox多因素回归分析结果表明：脂联素受体表达可以作为结肠癌患者无病生存的预后因素（RRerccl=6.44，95%CI：1.76~22.15，P＜0.01）。 结论 脂联素受体的表达水平与结肠癌及其Dukes分期、病理学分期及淋巴结转移具有一定的负相关性，脂联素受体可以作为Ⅱ、Ⅲ期结肠癌术后辅助化疗无病生存的预后评价指标。Abstract: Objective To explore the relationship between the expression of adiponectin receptors and prognosis of chemotherapy of colon cancer after radical resection. Methods One hundred colon cancer patients after radical resection all were received the chemotherapy of FOLFOX4 and were followed up for 2 years.The treatment cycles were 8-10 times.The expression adiponectin receptors of 80 cases of was detected by immunohistoohemical assay. Results The expression of adiponectin receptors in colon cancer was associated with the Dukes stage,tumor pathology types and lymph node metastasis（P＜0.05）.The survival time of Adiponectin receptors positive patients was longer than the negative patients in Kaplan-Meier survival curve. The Cox regression analysis showed that the expression of adiponectin receptors might be one of the prognostic factors of disease-free survival on colon cancer patients（RRerccl=6.44，95%CI:1.76-22.15，P＜0.01）. Conclusion Expression of adiponectin receptors in colon cancer is negatively associated with the Dukes stage,tumor pathology types and lymph node metastasis.Adiponectin receptors might be a prognostic factor of disease-free survival for post-operative adjuvant chemotherapy in Ⅱ，Ⅲ stage colon cancer.
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Key words:
- Colon cancer /
- Adiponectin receptors /
- Adjuvant chemotherapy /
- Prognosis
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