瘦素、雌激素及雌激素受体在肺癌组织中的表达及其相关性

杨成喜; 张蕾; 吴风雷; 冯文

doi:10.3971/j.issn.1000-8578.2013.06.016

瘦素、雌激素及雌激素受体在肺癌组织中的表达及其相关性

Relationship and Expression of Leptin，Estrogen and Estrogen Receptor in Lung Cancer Tissue

摘要

摘要: 目的探讨瘦素、雌激素及雌激素受体在肺腺癌及肺鳞癌组织中的表达及其意义。方法对41例肺腺癌和32例肺鳞癌组织及标本行免疫组织化学染色，检测瘦素、雌激素和雌激素受体的表达，并比较瘦素、雌激素及雌激素受体在肺腺癌及肺鳞癌组织中表达的差异，探讨其与肺腺癌之间的关系。结果 41例肺腺癌中瘦素、雌激素及雌激素受体阳性例数分别为32例（78.05%）、15例（36.59%）及25例（60.98%）；32例肺鳞癌中瘦素、雌激素及雌激素受体阳性例数分别为18例（56.25%）、5例（15.63%）及12例（37.5%），差异均有统计学意义（P＜0.05）。27例女性肺腺癌中，ER阳性例数为20例（74.07%）；14例男性肺腺癌中，ER阳性例数为5例（35.71%），差异有统计学意义（P＜0.05）。肺腺癌中瘦素、雌激素表达在性别、肺癌类型和临床分期间差异无统计学意义(P>0.05)。结论瘦素、雌激素及雌激素受体在肺腺癌组织中均呈高表达，女性肺腺癌中ER呈高表达，与肺腺癌的发生、发展和临床类型可能存在一定相关性。

Abstract: Objective To study the expressions of Leptin，Estrogen and Estrogen receptor(ER) in lung adenocarcinoma and squamous cell carcinoma. Methods The expressions of Leptin，Estrogen and Estrogen receptor were detected in 41 cases of lung adenocarcinoma and 32 cases of squamous cell carcinoma tissues by immunohistochemistry. Results In 41 cases of lung adenocarcinoma，the expression rates of Leptin, Estrogen and Estrogen receptor (ER) were 78.05%(32/41),36.59%(15/41) and 60.98%(25/41),respectively, and higher than those in 32 lung squamous cell carcinoma 56.25%(18/32),15.63%(5/32) and 37.5% (12/32), respectively （P<0.05）. In 27 female cases with adenocarcinoma，the expression rate of ER was increased, compared 14 male cases with adenocarcinoma, 74.07%(20/27) vs.35.71% (5/14) （P<0.05）. However, the expressions of Leptin, Estrogen had no relations to gender, histology types,clinical stage (P>0.05). Conclusion Leptin,Estrogen and ER were highly expressed in lung adenocarcinoma. ER was highly expressed in female adenocarcinoma. The expressions of Leptin,Estrogen and Estrogen receptor(ER) may associated with the carcinogenesis and development of lung adenocarcinoma.

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