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β-tubulin-Ⅲ基因表达与Ⅱ期非小细胞肺癌患者化疗敏感度的关系

江洪, 周星明, 王小红, 苏丹, 陶开义

江洪, 周星明, 王小红, 苏丹, 陶开义. β-tubulin-Ⅲ基因表达与Ⅱ期非小细胞肺癌患者化疗敏感度的关系[J]. 肿瘤防治研究, 2013, 40(06): 568-571. DOI: 10.3971/j.issn.1000-8578.2013.06.015
引用本文: 江洪, 周星明, 王小红, 苏丹, 陶开义. β-tubulin-Ⅲ基因表达与Ⅱ期非小细胞肺癌患者化疗敏感度的关系[J]. 肿瘤防治研究, 2013, 40(06): 568-571. DOI: 10.3971/j.issn.1000-8578.2013.06.015
JIANG Hong, ZHOU Xingming, WANG Xiaohong, SU Dan, TAO Kaiyi. Relationship between Expression Level of β-tubulin-Ⅲ and Sensitivity of Chemotherapy in Patients with Stage Ⅱ Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(06): 568-571. DOI: 10.3971/j.issn.1000-8578.2013.06.015
Citation: JIANG Hong, ZHOU Xingming, WANG Xiaohong, SU Dan, TAO Kaiyi. Relationship between Expression Level of β-tubulin-Ⅲ and Sensitivity of Chemotherapy in Patients with Stage Ⅱ Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(06): 568-571. DOI: 10.3971/j.issn.1000-8578.2013.06.015

β-tubulin-Ⅲ基因表达与Ⅱ期非小细胞肺癌患者化疗敏感度的关系

基金项目: 浙江省教育厅基金资助课题(2007-01345)
详细信息
    作者简介:

    江洪(1972-), 男,硕士,副主任医师,主要从事胸部肿瘤的基础及临床研究工作

    通讯作者:

    周星明,E-mail:hh110120@126.com

  • 中图分类号: R734.2

Relationship between Expression Level of β-tubulin-Ⅲ and Sensitivity of Chemotherapy in Patients with Stage Ⅱ Non-small Cell Lung Cancer

  • 摘要: 目的 探讨Ⅱ期非小细胞肺癌(NSCLC)中Ⅲ型β微管蛋白(β-tubulin-Ⅲ)mRNA表达与诺维本+顺铂(NP)方案化疗敏感度的关系。 方法 单基因定量法检测已手术Ⅱ期NSCLC患者肿瘤组织中β-tubulin-ⅢmRNA表达,所有患者行NP方案化疗,并随访患者的无瘤生存时间(DFS)和总体生存率(OS),统计学分析β-tubulin-ⅢmRNA表达水平与患者DFS和OS的关系。 结果 73例患者的OS与β-tubulin-Ⅲ的表达有关(P<0.01),患者的DFS与β-tubulin-Ⅲ的表达及淋巴结转移情况有关(P<0.01)。β-tubulin-Ⅲ低表达者的OS、DFS均高于β-tubulin-Ⅲ高表达者(P<0.05)。 结论 Ⅱ期NSCLC患者肿瘤组织中β-tubulin-Ⅲ表达水平可能是预测患者预后及化疗敏感度的一个指标,为选择合适化疗药物提供参考。

     

    Abstract: Objective To explore the relationship between chemotherapy sensitivity and the expression level of β- tubulin-Ⅲ mRNA in patients with stage Ⅱ NSCLC. Methods The expression of β-tubulin-Ⅲ mRNA was measured by Quanti-Gene assay.All patients accepted NP chemotherapy, and disease-free survival time (DFS) and overall survival time (OS) was analyzed. Results The OS of patients was related with the expression level of β-tubulin-Ⅲ (P<0.01), the DFS was related with the expression level of β-tubulin-Ⅲ and lymph node metastasis (P<0.01).The OS and DFS in patients with lower-expression level of β- tubulin-Ⅲ were longer than those with over-expression (P<0.05). Conclusion The expression of β-tubulin-Ⅲ in patients with stage Ⅱ NSCLC might be a predictive factor for chemotherapy sensitivity and the prognosis,and a reference for agents choose.

     

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出版历程
  • 收稿日期:  2012-12-20
  • 修回日期:  2013-02-20
  • 刊出日期:  2013-06-24

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