Abstract: Objective To investigate the clinical manifestations,treatment and prognosis of myeloid sarcoma(MS). Methods Clinical data of 17 MS cases were retrospectively analyzed.Survival analysis was made by Kaplan-Meier method. Results The predilection sites had lymph nodes,breast,cervix and orbit.Eight cases of isolated myeloid sarcoma and 9 case leukemia myeloid sarcoma were observed.The overall survival rate at 1 year was （72.0±12.0）% and 3 years （45.7±14.4）%.The overall survival rate of 3 year in isolated myeloid sarcoma was （85.7±13.2）%，and （51.9±17.6）% in leukemia. Conclusion Prognosis in isolated myeloid sarcoma was better than that in leukemia myeloid sarcoma.Survival of myeloid sarcoma was related to types of disease and adverse prognostic factors.