高级搜索

HER-2、贫血和前白蛋白与胃癌预后的关系

王 萍, 刘 静, 何慧明, 苏梅芳, 胡国清

王 萍, 刘 静, 何慧明, 苏梅芳, 胡国清. HER-2、贫血和前白蛋白与胃癌预后的关系[J]. 肿瘤防治研究, 2013, 40(05): 439-443. DOI: 10.3971/j.issn.1000-8578.2013.05.007
引用本文: 王 萍, 刘 静, 何慧明, 苏梅芳, 胡国清. HER-2、贫血和前白蛋白与胃癌预后的关系[J]. 肿瘤防治研究, 2013, 40(05): 439-443. DOI: 10.3971/j.issn.1000-8578.2013.05.007
shu
WANG Ping, LIU Jing, HE Huiming, SU Meifang, HU Guoqing. Relationship between HER-2, Anemia, Prealbumin and Prognosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(05): 439-443. DOI: 10.3971/j.issn.1000-8578.2013.05.007
Citation: WANG Ping, LIU Jing, HE Huiming, SU Meifang, HU Guoqing. Relationship between HER-2, Anemia, Prealbumin and Prognosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2013, 40(05): 439-443. DOI: 10.3971/j.issn.1000-8578.2013.05.007
shu

HER-2、贫血和前白蛋白与胃癌预后的关系

  • 1.438000 湖北黄冈，黄冈市中心医院肿瘤科；2.华中科技大学同济医学院附属同济医院肿瘤科

详细信息
    作者简介:

    王萍（1979-），女，硕士，主治医师，主要从事胃肠道恶性肿瘤的诊治研究

    通讯作者:

    胡国清，E-mail：gqhu@tjh.tjmu.edu.cn

  • 中图分类号: R735.2

Relationship between HER-2, Anemia, Prealbumin and Prognosis of Gastric Cancer

  • 1.Department of Oncology，Huanggang Central Hospital,Huanggang 438000，China；2. Department of Oncology，Tongji Medical College，Huazhong University of Science and Technology

摘要

    摘要
  • 摘要: 目的 研究HER-2、术前贫血和前白蛋白水平与胃癌预后的关系。 方法 对2008年1月—2009年12月经手术病理确诊、有完整随访资料的103例Ⅲ～Ⅳ期胃癌患者进行回顾性分析。选择性别、年龄、组织学类型、肿瘤部位、肿瘤大小、浸润深度、临床分期、HER-2、术前血红蛋白和血清前白蛋白水平作为观察指标。采用Kaplan-Meier生存分析、Log rank 检验和Cox 比例风险模型进行单因素和多因素分析；组间变量采用χ2检验或Fisher's精确检验。 结果 单因素分析显示N分期、HER-2、贫血、临床分期、前白蛋白水平均与胃癌的预后显著相关(P<0.05)；年龄、性别、肿瘤大小和部位与胃癌生存无相关性。Cox多因素分析显示HER-2过表达、贫血、白蛋白水平和临床分期是影响胃癌预后的独立因素(P<0.05)。 结论 （1）临床分期、HER-2、贫血和前白蛋白是胃癌的独立预后因素; （2）淋巴结转移与胃癌预后相关，但不是独立预后因素。（3）贫血的构成比与HER-2状态及临床分期有关，与前白蛋白无关。

     

    Abstract: Objective To investigate the relationship between HER-2, anemia, prealbumin and the prognosis of gastric cancer. Methods One hundred and three patients diagnosed as primary gastric cancer and staged at Ⅲ-Ⅳ from 2008 to 2009 were retrospectively analyzed. The clinical characteristics such as age, gender, histological type, tumor location, tumor size, infiltration depth, lymph node metastasis, clinical stage, the expression of HER-2, anemia and prealbumin concentration were observed. Survival curves were drawn with the Kaplan-Meier analysis. Comparisons were made with the Log rank test. Cox proportion risk model was established and χ2-test or Fisher's exact probability test was used to compare clinical characteristics. Results Lymph node metastasis, clinical stage, the expression of HER-2, anemia and prealbumin were identified as influencing factors about the prognosis of gastric cancer, while age, gender, histological type, tumor location and size were irrelevant with the survival of tumor patients. Multiple logistic regression analysis showed that independent and significant factors associated with the prognosis of gastric cancer were clinical stage, the expression level of HER-2, anemia and prealbumin concentration(P<0.05). Conclusion （1）HER-2 over-expression, anemia and low prealbumin concentration are the independent and significant factors on the prognosis of gastric cancer. （2）Lymph node metastasis is the influencing but not the independent factor on the prognosis of gastric cancer.（3）There is a significant difference on the proportion of anemia between HER-2 positive group and negative group, and the same result is found in stage Ⅲ group and stage Ⅳ group but not in prealbumin groups.

     

    • HTML全文
    • 参考文献(16)
  • [1] Yang L.Incidence and mortality of gastric cancer in China[J]. World J Gastroenterol, 2006,12 (1):17-20.
    [2] Lee J, Lim T, Uhm JE,et al.Prognostic model to predict survival following first-line chemotherapy in patients with metastatic gastric adenocarcinoma[J].Ann Oncol, 2007,18(5): 886-91.
    [3] Moelans CB, van Diest PJ, Milne AN, et al. Her-2/neu testing and therapy in gastroesophageal adenocarcinoma[J]. Pathol  Res Int,2010,2011:674182.
    [4] Xiao G,Tan M, Hu SW,et al. Expression feature and significance of E-cadherin and C-erbB-2 in gastric carcinoma[J].Guo Ji Yi Yao Wei Sheng Dao Bao,2008,14(13):44-7.[肖刚,谭敏,胡少为,等.E- cadherin、C-erbB-2在胃癌中的表达特点及意义[J].国际医药卫生导报,2008, 14 (13):44-7.]
    [5] Sakai K,Mori S,Kawamoto T,et al.Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas[J]．J Natl Cancer Inst,1986,77(5):1047-52．
    [6] Gao J, Chen HL, Xue JL,et al.Correlation of the expression of EMMPRIN and HER-2 proteins with the invasiveness and metastasis of human gastric carcinoma[J].Shi Jie Hua Ren Xiao Hua Za Zhi,2009, 17(19):1952-6.[高俊，陈洪雷，薛敬玲，等. EMMPRIN、HER-2蛋白表达与胃癌侵袭转移的关系[J].世界华人消化 杂志,2009,17(19):1952-6.]
    [7] Yan SY, Hu Y, Fan JG,et al. Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma[J]. World J Gastroenterol，2011,17(11):1501-6.
    [8] Grabsch H, Sivakumar S, Gray S,et al. HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series[J].Cell Oncol, 2010,32(1-2):57-65.
    [9] Wei W, Gao Y, Wang LW,et al. The relationship between cellular immunity and quality of life in patients with tumor associated anemia[J]. Zhong Liu,2010, 30(5)：406-9.[魏玮,高勇,王理伟,等.细胞 免疫状况与肿瘤相关性贫血患者生活质量的关系[J].肿瘤,2010, 30(5):406-9.]
    [10] Zhu BD, Wong J, Zhang JF,et al. Nutritional assessment of patients with cancer[J]. Zhongguo Zhong Liu Lin Chuang Yu Kang Fu,2002, 9（1）:62-4.[朱步东，翁洁，张金芳，等.恶性肿瘤病人营养状况的评 价[J]. 中国肿瘤临床与康复,2002, 9（1）:62-4.]
    [11] Pan XT, Lu Y, Cheng X, et al. Analysis of change of hemoglobin and anemia incidence for 3 079 cancer patients[J]. Zhonghua Zhong Liu Fang Zhi Za Zhi,2008,15(20):1540-3.[潘湘涛，陆晔，程旭，等. 癌症患者治疗前后血红蛋白变化及贫血发生情况的调查分析[J]. 中华肿瘤防治杂志,2008,15(20):1540-3.]
    [12] Li YQ,Jiang SH,Zhou T. Evaluation on the nutritlonal status of the middle and last phases cancer patients[J]. Zhong Liu Fang Zhi Za Zhi,2000,7(4):340.[李宇清,江素华,周涛.中晚期肿瘤患者的营养 状况研究[J]. 肿瘤防治杂志,2000,7(4):340.]
    [13] Gianotti L, Braga M. Revising concepts of artificial nutrition in contemporary surgery: from energy and nitrogen to immuno-metabolic support[J]. Nutr Hosp,2011,26(1):56-67.
    [14] Devoto G, Gallo F, Marchello C,et al.Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients[J]. Clin Chem,2006,52(12): 2281-5.
    [15] Wang JJ,Yu GZ. Clinicopathology and molecular biology in the prognosis of gastric carcinoma[J]. Lin Chuang Zhong Liu Xue Za Zhi,2008, 13（8）:673-6.[王杰军，于观贞.胃癌预后的临床病理及分子生 物学研究进展[J].临床肿瘤学杂志,2008, 13（8）:673-6.]
    [16] Chen GQ, Huang ZY. Cox  analysis of prognostic factors for patients with gastric cancer after radical resection[J].Ai Zheng Jin Zhan,2009,7(2):221-3.[陈光群,黄志有.胃癌根治术后影响预后因素Cox分 析[J].癌症进展,2009,7(2):221-3.]
    • 相关文章
    • 施引文献
    • 资源附件(0)
计量
  • 文章访问数:  2211
  • HTML全文浏览量:  26
  • PDF下载量:  356
  • 被引次数: 0
出版历程
  • 收稿日期:  2012-06-26
  • 修回日期:  2012-09-26
  • 刊出日期:  2013-05-24

目录

摘要
HTML全文
    参考文献(16)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    下载中心

    友情链接

    联系我们

    地址：武汉市洪山区卓刀泉南路116号（430079）

    电话：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    邮件订阅 RSS
    总访问量：12446093 今日访问：23316

    版权所有 © 《肿瘤防治研究》编辑部 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    本系统由北京仁和汇智信息技术有限公司开发  百度统计

    x 关闭 永久关闭