Correlation between Molecular Subtypes and Clinical Features in Invasive Ductal Carcinoma of Breast
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摘要: 目的 探讨乳腺浸润性导管癌不同分子亚型的分布，并分析各分子亚型与临床特征的关系。 方法 收集2006年1月-2011年6月明确诊断为乳腺浸润性导管癌病例100例，根据雌激素受体（ER）、孕激素受体（PR）、表皮生长因子受体-2（HER-2）的表达情况划分为四型，进一步分析不同分子亚型与浸润性导管癌临床特征的关系。 结果 100例中Luminal A型所占比例最大为65%，7%为Luminal B型, Triple Negative型占17%，Her-2(+)型占11%。各分子亚型乳腺浸润性导管癌患者发病年龄主要集中在40~59岁之间，占73%，Luminal A型发病年龄主要集中在40~49岁，而其他三型主要分布于50~59岁，四型在不同年龄组的分布上差异有统计学意义（P＜0.05）；Luminal A型淋巴转移发生率仅为30.1%，而Luminal B型与Her-2(+)型淋巴转移发生率较高，分别为71.4%及63.6%，各分子亚型的腋窝淋巴结转移率有显著差异（P＜0.05）；病理组织学分级Ⅰ级中Luminal A型所占比例最高，而Triple Negative型主要以Ⅲ级为主,差异具有统计学意义（P＜0.05）。 结论 乳腺浸润性导管癌各分子亚型分布差异具有统计学意义，各分子亚型与其临床特征关系密切。Abstract: Objective To investigate the distribution of different molecular subtypes of invasive ductal carcinoma of breast(IDC)，and analyze the correlation between molecular subtypes and clinical features. Methods A total of 100 patients with IDC from January 2006 to June 2011 were classified into four different subtypes according to estrogen receptor (ER), progestogen receptor (PR) and epidermal growth factor-2 (HER-2)，and analyze their relation to the clinical features of IDC. Results Among all 100 cases,Luminal A subtype was the majority (65％), triple negative was the second largest group(17% ), and Her-2 enriched and Luminal B type are the smallest groupes (17% and 7%, respectively). The ages of patients of IDC subtype were mainly between 40 and 59 (73%).The ages of patients of Luminal A subtype were mainly between 40 and 49.The ages of the patients of the other three molecular subtypes were mainly between 50 and 59(P<0.05) . The distributions in different age groups had statistic significance (P<0.05). There were more lymph nodes metastasis in Luminal B(71.4%) and HER-2 enriched (63.6%) groups(P＜0.05) than in Luminal A group(30.1%). The axillary lymph nodes metastasis rates of different molecular subtypes varied significantly (P<0.05). As for histopathologic grading,Luminal A patients were mainly gradeⅠ, and most Triple Negative patients were grade Ⅲ（P＜0.05）. The difference had statistic significance (P<0.05). Conclusion The distributions of different molecular subtypes of IDC has significant difference．The molecular subtypes are related to the clinical features of IDC.
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Key words:
- Invasive ductal carcinoma /
- Molecular subtype /
- Clinical feature
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