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广西地区1 278例老年人结直肠癌临床流行病学分析

甘嘉亮, 高枫, 曹云飞, 龙恒, 甘勇升

甘嘉亮, 高枫, 曹云飞, 龙恒, 甘勇升. 广西地区1 278例老年人结直肠癌临床流行病学分析[J]. 肿瘤防治研究, 2013, 40(01): 98-101. DOI: 10.3971/j.issn.1000-8578.2013.01.025
引用本文: 甘嘉亮, 高枫, 曹云飞, 龙恒, 甘勇升. 广西地区1 278例老年人结直肠癌临床流行病学分析[J]. 肿瘤防治研究, 2013, 40(01): 98-101. DOI: 10.3971/j.issn.1000-8578.2013.01.025
Gan Jialiang, Gao Feng, Cao Yunfei, Long Heng, Gan Yongsheng. Clinical Epidemiologic Analysis of 1 278 Cases of Elderly Patients with Colorectal Carcinoma in Guangxi Region[J]. Cancer Research on Prevention and Treatment, 2013, 40(01): 98-101. DOI: 10.3971/j.issn.1000-8578.2013.01.025
Citation: Gan Jialiang, Gao Feng, Cao Yunfei, Long Heng, Gan Yongsheng. Clinical Epidemiologic Analysis of 1 278 Cases of Elderly Patients with Colorectal Carcinoma in Guangxi Region[J]. Cancer Research on Prevention and Treatment, 2013, 40(01): 98-101. DOI: 10.3971/j.issn.1000-8578.2013.01.025

广西地区1 278例老年人结直肠癌临床流行病学分析

基金项目: 广西教育厅科研资助项目(201012MS039,201012 MS041);广西研究生教育创新计划资助项目(2011105981002D34)
详细信息
    作者简介:

    甘嘉亮(1972-),男,博士在读,副主任医师,主要从事结直肠癌基础与临床研究

  • 中图分类号: R735.3

Clinical Epidemiologic Analysis of 1 278 Cases of Elderly Patients with Colorectal Carcinoma in Guangxi Region

  • 摘要: 目的 分析60岁以上老年人结直肠癌的临床流行病学特征 。方法从广西医科大学第一附属医院病案信息科数据库导出结直肠肛门外科2003年1月—2010年12月住院病例资料,其中有病理诊断的结直肠癌初次住院患者2 810例,根据年龄分为老年组(≥60岁)、中年组(36~59岁)和青年组(≤35岁),比较三组的病例资料。结果老年人结直肠癌发病中位年龄为69岁,男女比为1.97∶1;肿瘤以直肠、乙状结肠和右半结肠为主要部位;术前心血管疾病、肺部炎症性疾病、Ⅱ型糖尿病和结直肠腺瘤合并率为13.46%、4.15%、7.36%、7.20%,明显高于中、青年组(P<0.05);术前癌性肠梗阻合并率6.89%,高于中年组(P<0.05);同时性肝转移率为11.58%,不同年龄组相比差异无统计学意义(P>0.05);管状腺癌为主要组织学类型,占86.85%,高度恶性组织学类型包括黏液腺癌、印戒细胞癌和未分化癌,占4.46%,明显低于中、青年组(P<0.05)。结论广西地区老年人群结直肠癌患者中,男性约为女性两倍,女性患者比例未出现明显增加;临床以术前基础并发症多、比较容易发生癌性肠梗阻、伴发结直肠腺瘤的比例较高为特点;病理以管状腺癌为主要组织学类型,高度恶性组织学类型较青壮年少,预后较好。

     

    Abstract: Objective To explore the clinical epidemiologic characteristics of the elderly patients with colorectal carcinoma (CRC). Methods Analysis and summary was made for 2 810 CRC patients pathologically confirmed in the first affiliated hospital of Guangxi medical university.These patients were divided into the elderly group,mid-aged group and young group. Results The median age was 69 years in the elderly patients and the ratio of male to female was 1.97∶1.Rectum,sigmoid and right colon were the main tumor size.The concomitant ratios of cardiovascular diseases,pulmonary inflammatory diseases,type 2 diabetes and colorectal adenoma in the elderly group,apparently higher than mid-aged group and young group,were 13.46%,4.15%,7.36%,7.20%,respectively.The rate of the obstructive CRC in the elderly group and young group surpassed the one of in the mid-aged group.The patients with synchronous liver metastasis accounted for 11.58% of total elderly patients,and the difference among three groups did not show a statistical significance(P>0.05).The major histological type was tubular adenocarcinoma (86.85%).The highly malignant histological forms including mucinous carcinoma,signet ring cell cancer and undifferentiated carcinoma in the elderly group,was obviously lower than another two groups. Conclusion There are almost twice as many elderly male patients with CRC as elderly female ones in the Guangxi region,and the female percent did not increased evidently.The elderly patients with CRC had these features such as more concomitant preoperative basic diseases,occurred easily colorectal obstruction and with higher-rate colorectal adenoma.The major histological type in the elderly group was tubular adenocarcinoma,and the ratio of the highly malignant histological kinds was very lower,which indicated better prognosis.

     

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出版历程
  • 收稿日期:  2012-02-26
  • 修回日期:  2012-07-23
  • 刊出日期:  2013-01-24

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