Abstract: Objective To evaluate the effects of the intensity-modulated radiation therapy(IMRT) in the treatment of brain metastasis. Methods One hundred and thirty cases of patients with brain metastasis were randomly divided into two groups.Conventional radiotherapy groups:64 cases,the whole brain radiotherapy (WBRT) 36-40 Gy in advance,concomitantly boost to 50-60 Gy,2 Gy/time,five times per week.While intensity-modulated radiation treatment group:66 cases,the whole brain radiotherapy dose 39.2-39.6 Gy,brain metastasis dose 54-60 Gy,5 times/week for 23 times. Results After the treatment 3 months and 6 months,the 1-3 of brain metastasis patients,conventional radiation therapy group and the IMRT group of median overall survival time,efficient (CR+PR) and 1 year survival rates were 13 months,82%,59% and 88%,61%,14 months respectively.The number of brain metastasis more than three patients,conventional radiation therapy group and the IMRT group of median overall survival time,efficient (CR+PR) rate and 1 year survival rates were 9 months,73%,47% and 13 months,87.5%,59% respectively. Conclusion IMRT can be a more effective treatment method for the patients with multiple brain metastasis than conventional radiotherapy.