Expression and Significance of Osteopontin,survivin and bcl-2 in Cervical Neoplasms
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摘要: 目的 研究骨桥蛋白(osteopontin，OPN)、survivin及bcl-2在宫颈病变中的表达及其临床意义。方法应用免疫组织化学SP法，检测74例宫颈癌、20例高级别上皮内瘤变、20例低级别上皮内瘤变以及24例慢性宫颈炎组织中OPN、survivin、bcl-2的表达。结果OPN、survivin、bcl-2在四组中阳性率的表达差异均有统计学意义（P<0.01）。组间分析显示宫颈癌、高级别上皮内瘤变、低级别上皮内瘤变与慢性宫颈炎相比，三者阳性率的表达差异均有统计学意义（P<0.05）。低级别上皮内瘤变与宫颈癌之间差异有统计学意义(P<0.05)，而高级别上皮内瘤变与宫颈癌之间差异无统计学意义(P>0.05)。OPN的表达与survivin、 bcl-2的表达呈正相关(P<0.01)。OPN、survivin的表达与宫颈癌组织学分级、FIGO分期和淋巴结转移呈正相关（P<0.05）。结论OPN在宫颈癌中高表达，提示OPN与宫颈癌的发生、发展密切相关。宫颈上皮内瘤变及宫颈癌组织中OPN的表达与survivin、 bcl-2的表达密切相关。Abstract: Objective To study the expressions and clinical significance of osteopontin(OPN),survivin,bcl-2 in cervical intraepithelial neoplasia(CIN) and cervical carcinoma. Methods By immunohistochemystry method(S-P),the expressions of OPN,survivin and bcl-2 in 74 cases of cervical carcinoma,20 cases of high grade CIN (H-CIN),20 cases of low grade CIN(L-CIN) and 24 cases of chronic cervicitis were examined. Results The expressions of OPN,survivin and bcl-2 were obvious difference among four groups(P<0.01).And there was obvious difference between cervical carcinoma,H-CIN,L-CIN and chronic cervicitis (P<0.05).There was statistically significant correlation between L-CIN and cervical carcinoma (P<0.05),but not H-CIN and cervical carcinoma (P>0.05).The expression of OPN was positively associated with survivin ，bcl-2(P<0.01),and it was also positively associated with differentiated grade,FIGO staging and lymph nodal involvement (P<0.05). Conclusion OPN was more highly expressed in cervical carcinomas,which suggested that OPN was intimately correlated with growth and development of cervical carcinoma.And there was intimate correlation between the expression of OPN and survivin,bcl-2 in cervical intraepithelial neoplasia and cervical carcinoma.
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Key words:
- Osteopontin /
- survivin /
- bcl-2 /
- Cervical carcinoma /
- Cervical intraepithelial neoplasia
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