Influence and Significance of TAM,CEA and CA72-4 for Chemotherapy in Advanced Gastric Cancer
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摘要: 目的探索化疗对晚期胃癌TAM、CEA、CA72-4的影响及临床意义。方法应用电化学免疫发光法对49例胃癌患者化疗前后血清中CEA、CA72-4进行检测；应用生化法对其血清TAM进行检测，并均与健康对照组进行比较。结果晚期胃癌患者化疗后血清中TAM、CEA、CA72-4分别为（99.00±17.00) u/ml、(24.17±7.54) ng/ml、(48.44±17.36) u/ml ；健康对照组分别为（70.00±12.00) u/ml、(4.24±1.28) ng/ml、(5.49±1.89)u/ml，两组差异具有统计学意义（P<0.01）；亚组分析显示化疗有效的病例（PR+SD）化疗前后TAM 分别为(123.00±21.00)u/ml、（97.00±16.00） u/ml；CEA、CA72-4化疗前分别为(25.80±2.57)ng/ml、(47.69±13.19)u/ml ，化疗后分别为(21.56±7.87) ng/ml、(38.47±14.23) u/ml，差异有统计学意义（P<0.01，P<0.05）。临床进展的病例(PD)化疗前TAM、CEA分别为(117.00±18.00) u/ml 和(21.34±5.68) ng/ml，化疗后分别为（140.00±17.00） u/ml和（30.94±8.79） ng/ml ，差异有统计学意义（P<0.01）；CA72-4化疗前后分别为（41.78±11.99） u/ml和（50.34±17.06） u/ml，差异有统计学意义(P<0.05)。结论TAM、CEA、CA72-4的联合检测可作为一种评价化疗效果的早期预测指标。Abstract: Objective To explore the effect of late gastric cancer chemotherapy on expression of TAM CEA,CA72-4 and clinical significance. Methods Application of the method of electrochemical immune shine gastric cancer patients in 49 cases before and after chemotherapy was used to detect plasma CEA and CA72-4;The biochemical method was used to test plasma TAM in patients compared with controls. Results In patients with advanced stomach cancer after chemotherapy,the plasma levels of TAM,CEA,CA72-4 were (99.00±17.00) u/ml,(24.17±7.54) ng/ml,(48.44±17.36) u/ml,respectively.And in control group,they were(70.00±12.00 )u/ml,(4.24 ±1.28) ng/ml,(5.49±1.89 )u/ml respectively.There was significant difference(P<0.01）.Sub group analysis showed that chemotherapy effective cases (PR+SD),the TAM level before chemotherapy or after chemotherapy was（123.00±21.00）u/ml or (97.00±16.00) u/ml,respectively;CEA and CA72-4 were (25.80±2.57) ng/ml,(47.69±13.19) u/ml or (21.56 ±7.87) ng/ml,(38.47± 14.23)u/ml,respectively.The difference was statistically significant(P<0.01,P<0.05).In clinical progress of cases (PD),the levels of TAM and CEA before chemotherapy or after chemotherapy were(117.00±18.00)u/ml and(21.34±5.68) ng/ml or were (140.00±17.00 )u/ml and (30.94±8.79)ng/ml,respectively.The difference had statistical significance (P<0.01);CA72-4 before or after chemotherapy was (41.78±11.99 )u/ml or(50.34±17.06 )u/ml,respectively.The difference was also statistically significant(P<0.05). Conclusion TAM,CEA,CA72-4 united detection can be used as evaluation index of chemotherapy curative effect for earlier forecast.
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Key words:
- TAM /
- CEA /
- CA72-4 /
- Late-stage gastric cancer
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[1] Qian JY,Sun WB.Malignant tumor patient serum tumor related material the meaning of detection [J].Zhongguo Ji Ceng Yi Yao,2009,16(8):1511.[钱纪银，孙蔚斌.恶性肿瘤患者血清肿瘤相关物质检测的意义[J].中国基层医药,2009,16(8)： 1511.] [2] Yang SJ,Wang WL,Liu MQ.Stomach cancer patients before and after surgery serum CA72-4 and CEA changes and clinical implications [J].Fang She Mian Yi Xue Za Zhi,2008,21(6):590-2.[杨士军,王文亮,刘满庆.胃癌患者手术前后血清 CA72-4和CEA的变化及临床意义[J].放射免疫学杂志,2008,21(6)：590-2.] [3] Kim DY,Kim HR,Shim JH,et al.Significance of serum and tissue carcinoembryonic antigen for the prognosis of gastric carcinoma patients[J]．J Surg Oncol,2000,74(3):185-92. [4] Duraker N,Celik AN．The prognostic significance of preoperatire serum CA 19-9 in patients with respectable gastric carcinoma:comparison with CEA[J].J Surg Oncol,2001,76(4):266-71. [5] Li Z,Gu JH.Stomach cancer serum tumor markers and clinical significance of detection [J].Jiangxi Yi Xue Jian Yan,2006,24 (3):262-3.[李舟，顾金华.胃癌血清肿瘤标志物的检测及临床意义[J]．江西医学检验,2006,24(3)：262-3.] [6] Zou X,Zhang XS,Sun L,et al.Serum tumor related material(BXTM) is tested in tumor auxiliary early diagnosis of value [J].Qilu Yi Xue Jian Yan,2004,15 (6):4.[邹雄，张晓时,孙玲,等.血清肿瘤相关物质(BXTM)检测用于肿瘤辅助早期诊断 的价值[J].齐鲁医学检验,2004,15(6)：4.] [7] Nie ZR,ZhaoYG,Gan GL,et al.BXTM,AFP,SF united detection of primary liver cancer patients to the clinical significance of [J].Xian Dai Yi Yao Wei Sheng,2009,25 (6):907-8.[聂忠荣,赵义刚,甘红灵,等.BXTM、AFP、SF联合检测对 原发性肝癌患者的临床意义[J].现代医药卫生,2009,25(6)：907-8.] [8] Carpelan-Homlstrm M,Louhimo J,Stenman UH,et al.CEA,CA 242,CA 19-9,CA 72-4 and hCGbeta in the diagnosis of recurrent colorectal cancer [J].Tumour Boil,2004,25(5-6):228-34. [9] Mattar R,Alves de Andrade CR,Difavero GM,et al.Preoperative serum levels of CA 72-4,CEA,CA 19-9,and alpha- fetoprotein in patients with gastric cancer [J].Rev Hosp Clin Fac Med Sao Paulo,2002,57(3):89-92. [10] Liao F,Qian J,Qin SK,et al.Sugar CA72 antigen 4 in different types of cancer of the stomach-the diagnosis value [J].Fang She Mian Yi Xue Za Zhi,2005,18(6):479.[廖峰，钱军，秦叔逵，等.糖类抗原CA72-4在不同类型胃癌中的诊断 价值[J].放射免疫学杂志,2005,18(6)：479.]
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