Influence and Significance of TAM,CEA and CA72-4 for Chemotherapy in Advanced Gastric Cancer
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摘要: 目的探索化疗对晚期胃癌TAM、CEA、CA72-4的影响及临床意义。方法应用电化学免疫发光法对49例胃癌患者化疗前后血清中CEA、CA72-4进行检测；应用生化法对其血清TAM进行检测，并均与健康对照组进行比较。结果晚期胃癌患者化疗后血清中TAM、CEA、CA72-4分别为（99.00±17.00) u/ml、(24.17±7.54) ng/ml、(48.44±17.36) u/ml ；健康对照组分别为（70.00±12.00) u/ml、(4.24±1.28) ng/ml、(5.49±1.89)u/ml，两组差异具有统计学意义（P<0.01）；亚组分析显示化疗有效的病例（PR+SD）化疗前后TAM 分别为(123.00±21.00)u/ml、（97.00±16.00） u/ml；CEA、CA72-4化疗前分别为(25.80±2.57)ng/ml、(47.69±13.19)u/ml ，化疗后分别为(21.56±7.87) ng/ml、(38.47±14.23) u/ml，差异有统计学意义（P<0.01，P<0.05）。临床进展的病例(PD)化疗前TAM、CEA分别为(117.00±18.00) u/ml 和(21.34±5.68) ng/ml，化疗后分别为（140.00±17.00） u/ml和（30.94±8.79） ng/ml ，差异有统计学意义（P<0.01）；CA72-4化疗前后分别为（41.78±11.99） u/ml和（50.34±17.06） u/ml，差异有统计学意义(P<0.05)。结论TAM、CEA、CA72-4的联合检测可作为一种评价化疗效果的早期预测指标。Abstract: Objective To explore the effect of late gastric cancer chemotherapy on expression of TAM CEA,CA72-4 and clinical significance. Methods Application of the method of electrochemical immune shine gastric cancer patients in 49 cases before and after chemotherapy was used to detect plasma CEA and CA72-4;The biochemical method was used to test plasma TAM in patients compared with controls. Results In patients with advanced stomach cancer after chemotherapy,the plasma levels of TAM,CEA,CA72-4 were (99.00±17.00) u/ml,(24.17±7.54) ng/ml,(48.44±17.36) u/ml,respectively.And in control group,they were(70.00±12.00 )u/ml,(4.24 ±1.28) ng/ml,(5.49±1.89 )u/ml respectively.There was significant difference(P<0.01）.Sub group analysis showed that chemotherapy effective cases (PR+SD),the TAM level before chemotherapy or after chemotherapy was（123.00±21.00）u/ml or (97.00±16.00) u/ml,respectively;CEA and CA72-4 were (25.80±2.57) ng/ml,(47.69±13.19) u/ml or (21.56 ±7.87) ng/ml,(38.47± 14.23)u/ml,respectively.The difference was statistically significant(P<0.01,P<0.05).In clinical progress of cases (PD),the levels of TAM and CEA before chemotherapy or after chemotherapy were(117.00±18.00)u/ml and(21.34±5.68) ng/ml or were (140.00±17.00 )u/ml and (30.94±8.79)ng/ml,respectively.The difference had statistical significance (P<0.01);CA72-4 before or after chemotherapy was (41.78±11.99 )u/ml or(50.34±17.06 )u/ml,respectively.The difference was also statistically significant(P<0.05). Conclusion TAM,CEA,CA72-4 united detection can be used as evaluation index of chemotherapy curative effect for earlier forecast.
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Key words:
- TAM /
- CEA /
- CA72-4 /
- Late-stage gastric cancer
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