Abstract: Objective To explore the effect of late gastric cancer chemotherapy on expression of TAM CEA,CA72-4 and clinical significance. Methods Application of the method of electrochemical immune shine gastric cancer patients in 49 cases before and after chemotherapy was used to detect plasma CEA and CA72-4;The biochemical method was used to test plasma TAM in patients compared with controls. Results In patients with advanced stomach cancer after chemotherapy,the plasma levels of TAM,CEA,CA72-4 were (99.00±17.00) u/ml,(24.17±7.54) ng/ml,(48.44±17.36) u/ml,respectively.And in control group,they were(70.00±12.00 )u/ml,(4.24 ±1.28) ng/ml,(5.49±1.89 )u/ml respectively.There was significant difference(P<0.01）.Sub group analysis showed that chemotherapy effective cases (PR+SD),the TAM level before chemotherapy or after chemotherapy was（123.00±21.00）u/ml or (97.00±16.00) u/ml,respectively;CEA and CA72-4 were (25.80±2.57) ng/ml,(47.69±13.19) u/ml or (21.56 ±7.87) ng/ml,(38.47± 14.23)u/ml,respectively.The difference was statistically significant(P<0.01,P<0.05).In clinical progress of cases (PD),the levels of TAM and CEA before chemotherapy or after chemotherapy were(117.00±18.00)u/ml and(21.34±5.68) ng/ml or were (140.00±17.00 )u/ml and (30.94±8.79)ng/ml,respectively.The difference had statistical significance (P<0.01);CA72-4 before or after chemotherapy was (41.78±11.99 )u/ml or(50.34±17.06 )u/ml,respectively.The difference was also statistically significant(P<0.05). Conclusion TAM,CEA,CA72-4 united detection can be used as evaluation index of chemotherapy curative effect for earlier forecast.