Abstract: Objective To explore the clinical efficacy of Shengxue pill in treating the changes of hematology of chemotherapy.MethodOne hundred and sixteen patients with gastrointestinal cancer were randomly divided into treatment group and control group．The treatment group was given combination therapy Shengxue pill and chemotherapy，and the control group was given chemotherapy alone．The changes of hematology were evaluated on the seventh day,fourteenth day,twenty-first day,and twenty-eighth day of chemotherapy.The QOL and some symptoms related to the Deficiency of Yang of Both Spleen and Kidney were evaluated as well. Results The total effective rate of the decrease of hematology of HGB,WBC,PLT in the treatment group was significantly lower than that of the control group．The QOL and the control of symptoms related to the Deficiency of Yang of Both Spleen and Kidney were better than that of the control group. Conclusion The clinical efficacy of Shengxue pill in treating the changes of hematology of chemotherapy is accurate，safe and reliable．