Abstract:
Objective To evaluate the normal and advanced MR features, pathological features of intracranial hemangiopericytomas in order to improve its diagnostic accuracy. Methods The normal and advanced MRI findings, pathological findings of 7 cases with intracranial hemangiopericytomas verified by pathology were retrospectively analyzed. Results MRI features of intracranial HPC included: 7 cases all were Outside brain parenchyma with average diameter (6.3±1.2) cm of focus area. Among the 7 cases, 6 of the cases were multilobulated, 7 were narrow based with dural, 4 had serpentine signal voids, and 6 had cystic degeneration or necrosis. The mix-intensity of T1WI, T2WI and T2WI-Flair markedly enhancement, showing a mild-moderate peritumoral edema around the tumor. The results from hyper-heterogenous intensity of DWI[ADC value was (1.15±0.36)] and of PWI [rCBV was (7.52±1.93); rCBF was (8.73± 1.78); and MTT was (1.62±0.29)]demonstrated a high perfusion in the tumor. The necrosis area showed low perfusion or no perfusion, while the peritumoral edema showed low perfusion. The results from MRS demonstrated that Cho/NAA, Cho/Cr, MI /N MI(normal MI) and Lac/Cr have significantly become higher and NAA /Cr has significantly become lower. Pathologically, tumors contained a large number of staghorn vessels with separated lobulations, oval shape tumor cells, and rich reticular fibers. Immunohistochemisty: 7 cases CD34(+), 5 cases EMA (-), 5 cases PR(-), 5 cases SMA(-), 4 cases GFAP(-),4 cases S-100 (-). Ki-67 ≤5% 3 cases, ≤10% 2 cases, and ≤ 20% 2 cases. Conclusion The morphology changes exhibited correlations with the information based on DWI, PWI and MRS for the patients with intracranial hemangiopericytomas. Thus, the application of multiple MIR plays an important role in the diagnosis and identification of intracranial hemangiopericytomas.