Abstract: Objective To explore the clinical application value of positron emission tomography-computed tomography using 18F-FLT. Methods Staging of TNM for a total of 23 patients with carcinoma was assessed with both 18F-FLT PET/CT and CT alone.The treatment strategy can be adjusted according to the result of ¹⁸F-FLT PET/CT and clinical data. Results (1)The TNM defined by CT was altered by 18F-FLT PET/CT in 4 of 23 cases.There was no significant difference between PET/CT and CT for the TNM staging（P>0.05）.T staging was changed in four cases,N staging was changed in three cases,and M staging was changed in only one case.(2)The treatment strategies for three cases have been changed. Conclusion ¹⁸F-FLT PET /CT fusion imaging allowed more accurate staging A better treatment efficacy can be obtained by optimizing the treatment strategy.