Abstract: Objective To investigate the expression of excision repair cross complementing-1 (ERCC1) and fibroblast growth factor receptor-2(FGFR2) in gastric carcinoma and explore their roles and clinical significance in the development of gastric carcinoma. Methods The expression of ERCC1 and FGFR2 in 27 resected patients with gastric carcinoma and corresponding 27 normal tissues were detected by the method of immunohistochemistry (SP two-step method). Results The positive expression rates of ERCC1 and FGFR2 were 33.3% and 44.4% in gastric carcinoma,respectively,both were lower than those in normal tissue which the positive expression rates were 88.9% and 81.5%,respectively.The expressions of both ERCC1 and FGFR2 showed a significant difference from those in normal gastric tissues (P<0.05).No difference of ERCC1 or FGFR2 protein was found among patients with different genders,ages,degrees of differentiation and pathological TNM stages (P>0.05).There was a positive relationship between the expressions of ERCC1 and FGFR2. Conclusion The low expression of ERCC1 and FGFR2 is related to occurrence and development of gastric carcinoma.There is a positive correlation between ERCC1 and FGFR2 protein expression in gastric carcinoma which might imply that ERCC1 could be one of the target gene in the FGF signaling pathways.