Abstract: Objective To assess the clinical effects of obturator prosthesis for the repair of maxillofacial defect for cancer were assessed. Methods 12 patients with T3~4 N0 M0 maxillary neoplasm were treated by total maxillecaomy and second time obturator prosthesis for the repair of maxillofacial,the patients were followed up at,1,3,6 month and one year after the surgery. Results All the patients were satisfied with the retention of prothesis,the improvement of appearance,all patients can chaw,swallow and pronounce. Conclusion The precise and second repair of maxillofasial defect by prosthesis after maxillectory can improve survival quality of patient.