Abstract: Objective To discuss correlation factor of diagnosis,treatment and prognosis of esthesioneuroblastoma (ENB). Methods The data of 12 patients with ENB treated from January 1994 to May 2010 were retrospectively reviewed in this study.one patient had modified Kadish stage A disease,five patients had modified Kadish stage B disease,three patients stage C,three patients in stage D.six patients were treated with comprehensive therapies including surgery,four patients were treated with surgery alone,one patient was treated with radiotherapy alone,one patient was treated with chemotherapy alone. Results The 5-year overall survival (OS) and disease free survival (DFS) of the whole group were 90.9% and 74.1% respectively.The 5-year OS of modified Kadish's stage A,B and C,D were 100% and 80.0%（χ²=1.20，P=0.27）.And the 5-year DFS were 100% and 44.4%（χ²=4.07，P=0.04）,respectively.The 5-year OS for patients with cervical lymph node metastasis and without cervical lymph node metastasis were 6.7% and 100% （χ²=2.67，P=0.10） The 5-year DFS were 33.3% and 87.5%（χ²=4.88，P=0.03）.The 5-year OS for patients treated with combined therapy and single treatment were 100% and 80.0%（χ²=1.20，P=0.27）,the 5-year DFS of them were 83.3% and 62.5%（χ²=0.35，P=0.88）,respectively. Conclusion It's difficult for early diagnose of ENB,the therapeutic effect of comprehensive therapy is better,radiotherapy is important for ENB.The prognosis of this disease is connected with the stage of the disease and lymph node metastasis.