Abstract: Objective To analyze the clinical and pathological prognostic factors of recurrent epithelial ovarian cancer. Methods Kaplan-meier survival curves,Log-rank test and Cox multivariate test regression were used to analyze clinical and pathological prognostic factors of relapse epithelial ovarian cancer in 92 cases with recurrent epithelial ovarian cancer which clinical pathology and follow-up data was completed. Results (1) Ninety-two patients with recurrent epithelial ovarian carcinoma cases overall median survival time was 18 months (95%CI:16.065~19.948).(2) Kaplan-Meier univariate analysis showed that FIGO stage,recurrence time from the last chemotherapy,recurrence site,the largest recurrence lesion,relapse with ascites,CA125 increased,secondary cytoreductive surgery,chemotherapy program for recurrence was the impact of important prognostic factor for re-treatment patients with recurrent EOC(P<0.1).But there was no relationship between age,grade of tumor cell,initial treatment plan and prognosis(P>0.1).(3)The Cox regression analysis showed that re-treatment regimen after relapse,the maximum recurrence of tumor size,recurrence site was an independent prognostic risk factor. Conclusion There are multiple clinical and pathological factors for affecting prognosis of recurrence epithelial ovarian cancer.Re-treatment regimen after relapsed,the maximum recurrence of tumor size,recurrence site are independent prognostic risk factors.