高级搜索

循环癌细胞和胃癌预后关系的Meta分析

郑刚, 王舒艺, 熊斌

郑刚, 王舒艺, 熊斌. 循环癌细胞和胃癌预后关系的Meta分析[J]. 肿瘤防治研究, 2012, 39(09): 1139-1145. DOI: 10.3971/j.issn.1000-8578.2012.09.021
引用本文: 郑刚, 王舒艺, 熊斌. 循环癌细胞和胃癌预后关系的Meta分析[J]. 肿瘤防治研究, 2012, 39(09): 1139-1145. DOI: 10.3971/j.issn.1000-8578.2012.09.021
Zheng, Wang Shuyi, Xiong Bin. Meta-analysis on Association of Circulating Tumor Cells with Prognosis in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(09): 1139-1145. DOI: 10.3971/j.issn.1000-8578.2012.09.021
Citation: Zheng, Wang Shuyi, Xiong Bin. Meta-analysis on Association of Circulating Tumor Cells with Prognosis in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(09): 1139-1145. DOI: 10.3971/j.issn.1000-8578.2012.09.021

循环癌细胞和胃癌预后关系的Meta分析

详细信息
    作者简介:

    郑刚(1974-),男,硕士,主治医师,主要从事消化道肿瘤的综合防治研究

    通讯作者:

    熊斌,E-mail:Binxiong88@yahoo.com

  • 中图分类号: R735.2

Meta-analysis on Association of Circulating Tumor Cells with Prognosis in Gastric Cancer

  • 摘要: 目的 探讨循环癌细胞(CTCs)和胃癌患者肿瘤分期、淋巴结转移和预后的相关性。方法计算机检索Embase、Medline和PubMed数据库,根据纳入和排除标准筛选文献,对入选文献的特征、研究结果的内容进行摘录和评价,并对各研究结果进行异质性检验和数据合并。结果入选文献18篇,均发表于2000—2011年。Ⅰ~Ⅱ期胃癌术前CTCs阳性率显著低于Ⅲ期患者(RR=0.63,95%CI:0.48~0.84),有淋巴结转移患者的CTCs阳性率高于无淋巴结转移的患者(RR=1.42,95%CI:1.20~1.68)。术前CTCs阳性的患者术后发生复发或转移的风险显著高于阴性患者(RR=2.42,95%CI:1.94~3.02),而且总体生存率更低(HR=1.83,95%CI:1.30~2.60)。结论术前CTCs检测阳性是胃癌患者预后不良的一个重要判断指标,可为胃癌的治疗决策提供参考。

     

    Abstract: Objective To study the relationship between lymph node metastasis, TNM stages, recurrence and overall survival with circulating tumor positive. Methods Embase, Medline and PubMed databases were searched by computer, based on inclusion and exclusion criteria for the screening literature. The research findings were extracted and evaluated by characteristics of selected literature. And all the results were tested for heterogeneity and data consolidation. Results Eighteen studies published between 2000 and 2011 matched to the selection criteria and were suitable for inclusion in this meta-analysis.There was a significantly higher incidence of circulating tumor cells (56.1%) in lymph node positive compared with negative groups (37.8%) [RR=1.42,confidence interval (95%CI) =1.20~1.68],and a significantly increased circulating tumor cells positive rate (36.7%) in TNM stage 1,2 compared with in stage 3 patients (56.6%) [RR=0.63,95%CI:0.48~0.84].Post-operative recurrence rate was significantly higher in the circulating tumor cell positive versus negative groups [RR=2.42,95% CI:1.94~3.02].Overall survival was significantly shorter in circulating tumor cells positive versus negative groups (HR=1.83,95%CI=1.30~2.60). Conclusion This study highlights the potential importance of circulating tumor cells detection in the peripheral blood of gastric cancers as a prognostic indicator and might benefit to the strategy of treatment.

     

  • [1] Pantel K,Alix-Panabières C.Circulating tumour cells in cancer patients:challenges and perspectives[J].Trends Mol Med,2010,16(9):398-406.
    [2] Dotan E,Cohen SJ,Alpaugh KR,et al.Circulating tumor cells:evolving evidence and future challenges[J].Oncologist,2009,14(11):1070-82.
    [3] Zhao S,Liu Y,Zhang Q,et al.The prognostic role of circulating tumor cells (CTCs) detected by RT-PCR inbreast cancer:a meta-analysis of published literature[J].Breast Cancer Res Treat,2011,130(3):809-16.
    [4] Rahbari NN,Aigner M,Thorlund K,et al.Meta-analysis shows that detection of circulating tumor cells indicatespoor prognosis in patients with colorectal cancer[J].Gastroenterology,2010,138(5):1714-26.
    [5] Stroup DF,Berlin JA,Morton SC,et al.Meta -analysis of observational studies in epidemiology:a proposal forreporting.Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group [J].JAMA,2000,283(15):2008-12.
    [6] Parmar MK,Torri V,Stewart L.Extracting summary statistics to perform meta-analyses of the publishedliterature for survival endpoints[J].Stat Med,1998,17(24):2815-34.
    [7] Majima T,Ichikura T,Takayama E,et al.Detecting circulating cancer cells using reverse transcriptase-polymerase chain reaction for cytokeratin mRNA in peripheral blood from patients with gastric cancer[J].Jpn JClin Oncol,2000,30(11):499-503.
    [8] Nishida S,Kitamura K,Ichikawa D,et al.Molecular detection of disseminated cancer cells in the peripheralblood of patients with gastric cancer[J].Anticancer Res,2000,20(3B):2155-9.
    [9] Miyazono F,Natsugoe S,Takao S,et al.Surgical maneuvers enhance molecular detection of circulating tumorcells during gastric cancer surgery[J].Ann Surg,2001,233(2):189-94.
    [10] Shin JH,Chung J,Kim HO,et al.Detection of cancer cells in peripheral blood of stomach cancer patients usingRT-PCR amplification of tumour-specific mRNAs[J].Aliment Pharmacol Ther,2002,16(Suppl 2):137-44.
    [11] Sumikura S,Ishigami S,Natsugoe S,et al.Disseminated cancer cells in the blood and expression of sialylatedantigen in gastric cance[J].Cancer Lett,2003,200(1):77-83.
    [12] Seo JH,Choi CW,Kim BS,et al.Follow-up study of peripheral blood carcinoembryonic antigen mRNA using reversetranscription-polymerase chain reaction as an early marker of clinical recurrence in patients with curativelyresected gastric cancer[J].Am J Clin Oncol,2005,28(1):24-9.
    [13] Illert B,Fein M,Otto C,et al.Disseminated tumor cells in the blood of patients with gastric cancer are anindependent predictive marker of poor prognosis[J].Scand J Gastroenterol,2005,40(7):843-9.
    [14] Ikeguchi M,Kaibara N.Detection of circulating cancer cells after a gastrectomy for gastric cancer[J].SurgToday,2005,35(6):436-41.
    [15] Wu CH,Lin SR,Hsieh JS,et al.Molecular detection of disseminated tumor cells in the peripheral blood ofpatients with gastric cancer:evaluation of their prognostic significance[J].Dis Markers,2006,22(3):103-9.
    [16] Uen YH,Lin SR,Wu CH,et al.Clinical significance of MUC1 and c-Met RT-PCR detection of circulating tumorcells in patients with gastric carcinoma[J].Clin Chim Acta,2006,367(1-2):55-61.
    [17] Kosaka Y,Mimori K,Fukagawa T,et al.Identification of the high-risk group for metastasis of gastric cancercases by vascular endothelial growth factor receptor-1 overexpression in peripheral blood[J].Br JCancer,2007,96(11):1723-8.
    [18] Koga T,Tokunaga E,Sumiyoshi Y,et al.Detection of circulating gastric cancer cells in peripheral blood usingreal time quantitative RT-PCR[J].Hepatogastroenterology,2008,55(84):1131-5.
    [19] Yie SM,Lou B,Ye SR,et al.Detection of surviving-expressing circulating cancer cells (CCCs) in peripheralblood of patients with gastric and colorectal cancer reveals high risks of relapse[J].Ann Surg Oncol,2008,15(11):3073-82.
    [20] Bertazza L,Mocellin S,Marchet A,et al.Survivin gene levels in the peripheral blood of patients with gastriccancer independently predict survival[J].J Transl Med,2009,7:111.
    [21] Kita Y,Fukagawa T,Mimori K,et al.Expression of uPAR mRNA in peripheral blood is a favourite marker formetastasis in gastric cancer cases[J].Br J Cancer,2009,100(1):153-9.
    [22] Qiu MZ,Li ZH,Zhou ZW,et al.Detection of carcinoembryonic antigen messenger RNA in blood using quantitativereal-time reverse transcriptase-polymerase chain reaction to predict recurrence of gastric adenocarcinoma[J].JTransl Med,2010,8:107.
    [23] Arigami T,Uenosono Y,Hirata M,et al.B7-H3 expression in gastric cancer:a novel molecular blood marker fordetecting circulating tumor cells[J].Cancer Sci,2011,102(5):1019-24.
    [24] Cao W,Yang W,Li H,et al.Using detection of surviving-expressing circulating tumor cells in peripheral bloodto predict tumor recurrence following curative resection of gastric cancer[J].J Surg Oncol,2011,103(2):110-5.
    [25] Kutun S,Celik A,Cem Kockar M,et al.Expression of CK-19 and CEA mRNA in peripheral blood of gastric cancerpatients[J].Exp Oncol,2010,32(4):263-8.
    [26] Mocellin S,Keilholz U,Rossi CR,et al.Circulating tumor cells:the ‘leukemic phase’ of solid cancers[J].Trends Mol Med,2006,12(3):130-9.
    [27] Bidard FC,Mathiot C,Delaloge S,et al.Single circulating tumor cell detection and overall survival innonmetastatic breast cancer[J].Ann Oncol,2010,21(4):729-33.
    [28] Van der Auwera I,Peeters D,Benoy IH,et al.Circulating tumour cell detection:a direct comparison between theCellSearch System,the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer[J].Br JCancer,2010,102(2):276-84.
计量
  • 文章访问数:  2266
  • HTML全文浏览量:  31
  • PDF下载量:  687
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-12-25
  • 修回日期:  2012-03-22
  • 刊出日期:  2012-09-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭