Abstract: Objective To assess the clinical efficacy and safety of preoperative intra-arterail infusion chemothrapy(IAIC+S)+surgery(S) versus Preoperative intravenous chemotherapy+S(IVC+S) or S alone for locally advanced gastric carcinoma. Methods PubMed（January,2000 to May,2011）,EM BASE(January,2000 to May,2011),Cochrane Library(Issue 4,2011),Chinese Biomedical Literature Database(January,2000 to May,2011),China Journal Full text Database(January,2000 to December,2007)， and Chinese Scientific Journals Full text Database(January,2000 to December,2007) were searched for relevant original published in any date.We also track back to the references to collect trails.Inclusion criteria were as follows:clinical controlled trails regardless of randomization were reported in English or Chinese.Two reviewers extracted data and assessed the quality of included trials independently.The RevMan 5.1 software was used for statistical analysis. Results Seven studies involving 792 patients were included.Meta-analysis showed that,between(IAIC+S) and (IVC+S),there was significant difference in radical resection rate,and the pooled RR（95%CI）was 1.70（1.41~2.05）.But in response rate,complications of postoperation and chemotherapy side effects,they all had no statistical difference.Between(IAIC+S) and S alone,RRs of radical and palliative resection rates（95％CI） were 1.30（1.16~1.45）and 0.58（0.42~0.79）respectively.All 1-year,3-year,4-year,5-year and overall survival had statistical signicance,with 1.11（1.03~1.20）,1.36（1.09~1.69）,1.70（1.35~2.14）and 1.85（1.30~2.65）,respectively.In postoperative complications,RRs （95％CI） of anastomotic leakage,abdominal infection and wound infection were 0.78（0.27~2.28），0.65（0.16~2.65） and 1.15（0.43~3.10）respectively,without statistical differences. Conclusion This study suggested that IAIC is an effective and safety method compared with IVC or S alone in improving radical resection rate and survival rate for locally advance gastric cancer.But in view of the poor quality of included studies,our result was needed to be furtherly confirmed.