Abstract: Objective To investigate survivin protein and risk factors in non-small cell lung cancer(NSCLC) through a systematic review. Methods The published studies were searched from the Cochrane Library(Issue 1,2011),Pubmed and CNKI databases,and other relevant journals were also handsearched to identify all the relevant case-control trials.Then the quality of the included trials was assessed and meta-analysis was performed by RevMan 4.2.10 software. Results A total of 31 studies were recruited.As for the positive rate of survivin expression,significant differences were discovered between NSCLC and normal lung tissues(OR=11.11,95%CI:5.92~20.83,P<0.05).No significant difference was shown among gender(OR=1.10,95%CI:0.87~1.40 P＞0.05),age(OR=1.05,95%CI:0.66~1.68,P＞ 0.05),smoking history(OR=1.18,95%CI:0.81~1.73,P＞0.05),and histologic subtype(OR=1.24,95%CI:0.90~1.73,P＞ 0.05),respectively.There were significant differences between T3~4 and T1~2(OR=2.20,95% CI:1.65~2.93,P<0.05),clinic stages Ⅲ~Ⅳ and clinic stages Ⅰ~Ⅱ(OR=2.79,95%CI:1.23~6.35,P<0.05),lymph node metastasis and non-lymph node metastasis(OR=2.14，95%CI:1.36~3.35,P<0.05),cell differentiation G3 and cell differentiation G1~G2(OR=1.98,95%CI=1.27~3.08,P<0.05).Moreover,the overall survival time was significantly shorter in patients with survivin expression(26.69%) than that in patients with absent survivin expression (62.20%)(OR=0.16，95%CI=0.04~0.66,P<0.05).Survivin expression was positively correlated with p53 (r=0.400,P<0.005)and Bcl-2(r=0.486,P<0.005). Conclusion Survivin expression increased malignant behaviors of NSCLC,and meanwhile substantial correlation is confirmed between survivin and both p53 and Bcl-2.