Measurement Psychology Assessment for Quality of Life Evaluated by QLQ-C30 in Patients with Nasopharyngeal Carcinoma
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摘要: 目的 对EORTC QLQ-C30(QLQ-C30)进行计量心理学考核，以考核该量表是否适合于鼻咽癌患者生存质量的评价。方法收集中山大学肿瘤医院的391名鼻咽癌患者的QLQ-C30和人口学资料，采用信度效度理论考核量表的信度、效度、区分度及项目反应理论考核条目的 项目功能差异（DIF）。结果除躯体功能和认知功能外，各个领域的Cronbach′s α系数均大于0.7。除认知功能和疲倦外，各个领域的分半系数均大于0.7。所有领域的重测系数都大于0.7。因子分析的结果显示实际的数据跟理论模型一致。不同放疗阶段的患者在大部分领域得分的差别具有统计学意义。项目反应理论结果显示条目在性别、年龄分组上没有一致性DIF和非一致性DIF。结论QLQ-C30是一个具有良好的信度、效度、区分度和计量心理学特征的癌症量表，操作性强，可用于鼻咽癌患者的生存质量评价。Abstract: Objective To assess the psychological characteristic of EORTC QLQ-C30 scale;and to measure whether QLQ-C30 scale was suitable to measure the QOL of nasopharyngeal carcinoma(NPC) patients. Methods The data of 391 NPC patients from Cancer Hospital of Sun Yat-Sen University were collected.The reliability,validity and discrimination of scale were assessed by reliability and validity theory.And differential item functioning(DIF) was reviewed by item response theory evaluation. ResultsCronbach′s α coefficients of QLQ-C30 domains were greater than 0.7,except physical function and cognitive function domain.Split-half reliability of QLQ-C30 domains was greater than 0.7,except physical function domain and fatigue.Test-retest coefficients of QLQ-C30 domains were greater than 0.7.The result of factor analysis showed that the data were consistent with the theoretical model.Most of the domain scores and dimension scores of patients in different radiotherapy stages were significantly different(P<0.05).All the items had not uniform or non-uniform DIF between different gender and age groups. Conclusion QLQ-C30 scale was a reliable and valid disease-specific instrument,with good receptiveness to evaluate QOL of NPC patients.
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Key words:
- Nasopharyngeal Carcinoma /
- QLQ-C30 /
- Reliability /
- Validity /
- Item response theory
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