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紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析

尹雪, 刘杰, 田金徽

尹雪, 刘杰, 田金徽. 紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析[J]. 肿瘤防治研究, 2012, 39(07): 851-854. DOI: 10.3971/j.issn.1000-8578.2012.07.022
引用本文: 尹雪, 刘杰, 田金徽. 紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析[J]. 肿瘤防治研究, 2012, 39(07): 851-854. DOI: 10.3971/j.issn.1000-8578.2012.07.022
Yin Xue, Liu Jie, Tian Jinhui. A Meta Analysis of Concurrent Radiotherapy Plus Paclitaxel and Cisplatin in Treatment of Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(07): 851-854. DOI: 10.3971/j.issn.1000-8578.2012.07.022
Citation: Yin Xue, Liu Jie, Tian Jinhui. A Meta Analysis of Concurrent Radiotherapy Plus Paclitaxel and Cisplatin in Treatment of Esophageal Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(07): 851-854. DOI: 10.3971/j.issn.1000-8578.2012.07.022

紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析

基金项目: 2011年度兰州大学中央高校基本科研业务费专项资金资助(lzujbky-2011-133)
详细信息
    作者简介:

    尹雪(1988-),女,本科,主要从事食管癌的放化疗研究

    通讯作者:

    田金徽,E-mail:tianjh@lzu.edu.cn

  • 中图分类号: R735.1

A Meta Analysis of Concurrent Radiotherapy Plus Paclitaxel and Cisplatin in Treatment of Esophageal Cancer

  • 摘要: 目的 评价紫杉醇联合顺铂同步放化疗综合治疗中晚期食管癌的临床疗效及安全性。方法计算机检索PubMed、EMBASE、Cochrane Library、CNKI等数据库,收集相关的随机对照试验(RCTs),按照入选标准,采用Rev Man 5.0统计软件进行统计学分析。结果共纳入6个随机对照试验,包括 559例患者。Meta分析结果显示,与单纯放疗比,紫杉醇联合顺铂同步放化疗可提高有效率,其RR值及95%CI可信区间为1.28(1.17,1.40),1、2、3年生存率RR值及95%CI分别为1.25(1.10,1.42)、1.44(1.18,1.76)、1.46(1.15,1.86)。但不良反应也提高,如放射性食管炎、消化道不良反应,其RR值及95%CI分别为2.49(1.02,6.08)、25.00 (3.49,179.25)。结论紫杉醇联合顺铂同步放化疗治疗中晚期食管癌疗效优于单纯放疗,不良反应随之增加,但大多可以耐受。

     

    Abstract: Objective To evaluate the clinical efficacy and safety of paclitaxel plus cisplatin chemotherapy combining concurrent radiotherapy on esophageal carcinoma. Methods We searched PubMed,EMBASE,Cochrane Library,CNKI,and other databases to collect randomized controlled trials (RCTs).According to the statistical analysis of RevMan5.0 statistical software. ResultsThe results were included in six randomized controlled trials,including 559 cases of patients.Meta analysis showed that in the treatment of advanced esophageal carcinoma,when compared with radiotherapy alone,the concurrent radiotherapy and chemotherapy can improve the efficiency,the RR value and 95% confidence interval were 1.28(1.17,1.40) and 1,2 or 3-year survival rate of RR values and 95% confidence interval are 1.25 (1.10,1.42),1.44(1.18,1.76),1.46(1.15,1.86),respectively.However,the toxicities also increased,such as the incidence of radioactive esophagitis and gastrointestinal adverse reactions were 2.49(1.02,6.08),25.00 (3.49,179.25),respectively. Conclusion The efficacy of pacli taxol plus cisplatin combined with concurrent radiotherapy on esophageal carcinoma is more effective than that of concurrent radiotherapy alone.Although the adverse reactions are increased at the same time,most of them can be tolerated.

     

  • [1] Swisher SG,Ajani JA,Komaki R,et al.Long-term outcome of phase Ⅱ trial evaluatingchemotherapy,chemoradiotherapy,and surgery for locoregionally advanced esophageal cancer[J].Int J Radiat OncolBiol Phys,2003,57(1):120-7.
    [2] Sun Y,Zhou JC.Manual of medical oncology[M].Beijing:People′s Medical Publishing House,2003:567.[孙燕,周际昌.临床肿瘤内科手册[M].北京:人民卫生出版社,2003:567.]
    [3] Ilson DH,Forastiere A,Arquette M,et al.A phase Ⅱ trial of paclitaxel and cisplatin in patients withadvanced carcinoma of the esophagus[J].Cancer J,2000,6(5):316-23.
    [4] Ohtsu A,Boku N,Muro K,et al.Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carinomaof the esophagua[J].J Clin Oncol,1999,17(9):2915-21.
    [5] Wu JL,Yang CL,Lan YQ,et al.Prospective effect of concurrent chemotherapy combined with radiotherapy versuschemotherapy alone in patients with middle-metastatic of relapsed esophageal cancer[J].Zhongguo Yi Xue ChuangXin,2008,5(32):1-3.[吴金龙,杨长领,兰跃强,等.同步放化疗联合与单纯化疗对中晚期食管癌疗效观察[J].中国医学创新,2008,5(32):1-3.]
    [6] Guo JX,Xu ZY,Chen J,et al.Effect of concurrent chemoradiotherapy with Paclitaxed and Cisplatin onlocallyadvanced esophageal cancer[J].Zhong Liu Xue Za Zhi,2006,12(3):214-6.[郭建新,徐正阳,陈俊,等.泰素加顺铂联合放疗对局部晚期食管癌的疗效观察[J].肿瘤学杂志,2006,12(3):214-6.]
    [7] Wan ZL,Ge Q,Cheng GJ,et al.Clinical analysis of radiation therapy combined with TP chemotherapy foresophageal cancer[J].Xian Dai Zhong Liu Yi Xue,2010,18(12):2378-9.[万志龙,葛琴,成国建,等.放疗联合TP方案化疗综合治疗食管癌 100 例临床分析[J].现代肿瘤医学,2010,18(12):2378-9.]
    [8] Cheng HH,Lin GS,Fu ZC,et al.Analysis of the effect of concurrent chemor adiotherapy on locally advancedesophageal carcinoma[J].Lin Chuang Zhong Liu Xue Za Zhi,2007,12(4):290-4.[程惠华,林贵山,傅志超,等.紫杉醇加顺铂同步放化疗治疗局部晚期食管癌的临床研究[J].临床肿瘤学杂志,2007,12(4):290-4.]
    [9] He MW,Lu G,Zhou JG.Paclitaxel plus cisplatin combined with radiotherapy in treatment of advanced esophagealcancer[J].Chongqing Yi Xue,2009,38(6):698-9.[何美文,鲁广,周建刚.紫杉醇+顺铂方案联合同步放疗治疗中晚期食管癌临床观察[J].重庆医学,2009,38(6):698-9.]
    [10] Yao J,Ye YL.Paclitaxel combined with cisplatin concurrent radiotherapy and chemotherapy for 25 patientswith partly advanced esophageal carcinoma[J].Jiang Xi Zhong Yi Yao,2009,3(40):29-30.[姚洁,叶永来.紫杉醇联合顺铂同步放化疗治局部晚期食管癌25例[J].江西中医药,2009,3(40):29-30.]
    [11] Wang JH,Chen DM.Weekly TP regimen versus triweekly TP regimen therapy in advanced esophageal carcinoma[J].Zhong Liu Ji Chu Yu Lin Chuang,2008,21(5):408-10.[王建红,陈冬梅.周剂量TP方案与三周方案治疗晚期食管鳞癌的临床疗效比较[J].肿瘤基础与临床,2008,21(5):408-10.]
    [12] Richel DJ,Vervenne WL.Systemic treatment of esophageal cancer[J].Eur J Gastroenterol Hepatol,2004,16(3):249-54.
    [13] Wu XF,Liu SH,Li MH.Clinical observation of radiotherapy combined with taxol chemotherapy on locallyadvanced esophageal carcinoma[J].Xian Dai Zhong Liu Yi Xue,2009,17(12):2356-8.[吴晓阜,刘思海,李明华.放疗联合紫杉醇治疗中晚期食管癌的临床观察[J].现代肿瘤医学,2009,17(12):2356-8.]
    [14] Scheff PB,Fant J,Horwitz SB.Promotion of microtubule assembly in vitro by taxol[J].Nature,1979,277(5698):665-7.
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出版历程
  • 收稿日期:  2011-08-22
  • 修回日期:  2011-12-08
  • 刊出日期:  2012-07-24

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