Abstract: Objective To study the clinical effect of Yanshu on primary hepatic carcinoma treated with interventional therapy. Methods A total of 82 patients with primary hepatic carcinoma were randomly divided into the treatment group(42 cases) and control group(40 cases). All patients concurrently received TACE,and the treatment group was additionally treated with Yanshu injection. The curative effects, survival period, clinical symptoms and toxic reactions were observed. Results There was no significant difference between two groups in total effective rates(P<0.05). However, there were significant differences in 24-months-survival-rates, clinical symptoms and toxic reactions between two groups(P<0.05). Conclusion TACE in combination with Yanshu can protect liver function, improve clinical symptoms, reduce toxic effects and prolong survival of patients.