Abstract: Objective To discuss the clinical features and outcome of malignant melanoma of the skin on foot. Methods From 1998 to 2010,61 patients with melanoma on foot were retrospectively analyzed in our department.The main treatments were surgery,chemotherapy and immunotherapy.All patients undergo operation,all patients were treated by toe resection,lesion resection and skin graft,or lesions resection with flap transfer.while 32 cases had groin lymph node reaction at the same time.The survival rate was statistics.Factors that might be related to survival,included tumor depth,ulcer and lymph node metastasis.Analyzed by Kaplan-Meier and Log-rank method. Results Fifty-three patients were followed,and 8 of them were lost to follow up 2 years later.The follow up period ranged from 1 to 10 years,4.5 years on average.Survival rates in 1,3 and 5 years were 77.0%(47/61)，58.5%(31/53) and 26.4%(14/53),respectively.The appearance and function of foot recovered well,and the local recurrence didn't appear.Among them,27 patients died from systemic metastasis,and regional groin lymph node recurrence appeared in twelve patients. Conclusion The rate of metastasis in patients with melanoma on foot was higher.Factors related to survival,included tumor ulcer and depth,and lymph node metastasis,are analyzed by Kaplan-Meier and Log-rank method，the tumor depth may play a more important role in operation.Combination therapy included surgery,chemotherapy,and immunotherapy is the main treatment.