Abstract: Objective To analyze the clinicopathological characteristics of patients with SRC in comparison with non- signet ring cell carcinoma(NSRC) of the stomach. Methods Retrospective study on the clinicopathological characteristics of 110 patients with SRC and 326 patients with NSRC. Results In this study,the proportion of men and women in SRC (1.4∶1) is lower than in the NSRC group (2.5∶1)(P<0.01);among all the patients younger than 60 years old,the morbidity of SRC(43.6%) is higher than that of NSRC(30.9%) (P<0.05);the proportionality of SRC is 31.4% of all the patients with gastric cancer in stage Ⅰ,and 23.3% in the other stages(P<0.05);the proportion of the tumor which infiltrate into submucosa is lower in the SRC group(70%)than the NSRC group(86.9%)(P<0.001);but no significant differences in tumor location or lymph node metastasis between two groups(SRC and NSRC). Conclusion Signet ring cell carcinoma happens more commom in young females and the incidence rate is higher in early carcinoma and infiltrates more slowly in submucosa than mucosa.