Abstract: Objective To observe metastatic effect of Hui medicine Aikangfang in C57 mice Lewis lung cancer cells and test bcl-2 expression in each mice tumor tissue. Methods Fifty-five tumor-bearing mice were randomly divided into model group,chemotherapy(CTX) group,low-dose group,low-dose with chemotherapy group and high-dose with chemotherapy group.After treatment,observing the lung surfaces metastasis and bcl-2 protein expressions of each mouse. Results （1） Lung metastases changes:compared with tumor-bearing model,the more than mice lung metastases is statistically significant difference (P<0.05).（2） bcl-2 expression:compared with tumor-bearing model,the more than bcl-2 expression is statistically significant difference (P<0.01). Conclusion Hui medicine Aikangfang can resist lung cancer metastasis in mice and reduce bcl-2 expression.