A Constructive Experimental Study on Prevention of Chemotherapy-induced Nausea and Vomiting by Ginger-partitioned Moxibustion on Acupoint of Zusanli
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摘要: 目的 观察隔姜艾灸足三里预防化疗所致的恶心呕吐的效果，探索用祖国传统医学的方法减轻化疗胃肠道不良反应的可行性。方法 采用前瞻性自身交叉对照法。将30例病例分为三组，每组均化疗3周期，3周期中采用艾灸—昂丹司琼—艾灸+昂丹司琼三种方法循环使用，观察各组的恶心呕吐情况和化疗前1天、化疗后第1天、第9天的血清5-HT（五羟色胺）水平。结果 三组的止吐有效率分别为80.0%、83.3%和93.3%，差异无统计学意义（P>0.05）；化疗前1天、化疗后第1天、第9天三组间血清5-HT水平差异均无统计学意义（P>0.05）；艾灸组和艾灸+药物组化疗后第9天的血清5-HT水平均明显低于化疗后第1天，差异有统计学意义（P<0.05）；药物组化疗后第9天5-HT水平与化疗后第1天相比，差异无统计学意义（P>0.05）。结论 艾灸与昂丹司琼止吐机制不同，但效果相近，且艾灸费用低廉、不良反应小、操作简便，值得临床推广。中西医结合使用效果更佳。Abstract: Objective To research the prevention of ginger-partitioned moxibustion on Zusanli against chemotherapy-induced nausea and vomiting,and to explore the feasibility of traditional medicine to relieve the gastrointestinal toxicity of chemotherapy. Methods A prospective crossover comparison method was employed.Thirty cases with three cycles of chemotherapy were divided into three groups: moxibustion group,ondansetron group,and moxibustion + ondansetron group.And serum 5-HT levels were tested in the first day before chemotherapy,the first day and the ninth day after chemotherapy. Results The antiemetic response rate was 80.0%,83.3% and 93.3% respectively in three groups,without significant difference (P＞0.05).The serum 5-HT levels were not significantly different (P＞0.05) among the three groups before and after chemotherapy.However,in moxibustion group and moxibustion + ondansetron group,the serum 5-HT levels in the first day after chemotherapy were significantly higher than those in the first day before chemotherapy and the ninth day after chemotherapy (P＜0.05).In ondansetron group,the 5-HT levels in the first day after chemotherapy was significantly higher than those in the first day before chemotherapy (P＜0.05),but similar to those in the ninth day (P＞0.05). Conclusion Moxibustion had different antiemetic mechanisms,compared to ondansetron,although the effect was similar.Moxibustion was a low-cost,little side effects,simple operation,especially combined with agents.
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Key words:
- Chemotherapy /
- Nausea /
- Vomiting /
- Ginger moxibustion /
- Zusanli /
- 5-hydroxy tryptamine
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