高级搜索

565例双侧原发性乳腺癌临床病理特征分析

张晟, 张霄蓓, 郝晓甍, 张瑾

张晟, 张霄蓓, 郝晓甍, 张瑾. 565例双侧原发性乳腺癌临床病理特征分析[J]. 肿瘤防治研究, 2012, 39(06): 632-636. DOI: 10.3971/j.issn.1000-8578.2012.06.005
引用本文: 张晟, 张霄蓓, 郝晓甍, 张瑾. 565例双侧原发性乳腺癌临床病理特征分析[J]. 肿瘤防治研究, 2012, 39(06): 632-636. DOI: 10.3971/j.issn.1000-8578.2012.06.005
Zhang Sheng, Zhang Xiaobei, Hao Xiaomeng, Zhang Jin. Analysis of Clinical and Pathological Features of 565 Cases of Bilateral Primary Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 632-636. DOI: 10.3971/j.issn.1000-8578.2012.06.005
Citation: Zhang Sheng, Zhang Xiaobei, Hao Xiaomeng, Zhang Jin. Analysis of Clinical and Pathological Features of 565 Cases of Bilateral Primary Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 632-636. DOI: 10.3971/j.issn.1000-8578.2012.06.005

565例双侧原发性乳腺癌临床病理特征分析

基金项目: 科技部国际合作重大资助项目(2010DFB30270)
详细信息
    作者简介:

    张晟(1976-),男,副主任医师,主要从事乳腺肿瘤的研究

    通讯作者:

    张瑾,E-mail:davidz9132002@yahoo.com

  • 中图分类号: R737.9

Analysis of Clinical and Pathological Features of 565 Cases of Bilateral Primary Breast Cancer

  • 摘要: 目的 探讨原发性双侧乳腺癌(bilateral primary breast cancer,BPBC)患者的临床病理特征。方法收集1971年1月—2011年11月间我院诊治的565例双乳癌患者临床资料。对比分析同时性双乳癌(bilateral synchronous breast cancer)和异时性双乳癌(bilateral asynchronous breast cancer)在发病年龄、发病间隔、月经情况、家族史、肿瘤体积、临床分期、淋巴结数目、激素受体等临床病理特征的差异。结果异时性双乳癌首发癌年龄要早于同时性双乳癌(P<0.05)。同时性/异时性双乳癌在家族史、肿瘤体积、临床分期、腋淋巴结数目方面的差异均无统计学意义(P>0.05)。同时性双乳癌两侧病灶内分泌受体表达一致率高于异时性双乳癌(P<0.01)。无论同时性或异时性双乳癌其第二癌的肿瘤体积、临床分期和腋淋巴结情况都优于第一癌。同时性双乳癌与异时性双乳癌5年无病生存率与10年总生存率之间的差异有统计学意义(P<0.01)。 结论双侧原发性乳腺癌第二癌与第一癌可视为两个完全不同的癌灶。单侧发生乳癌之后对侧乳癌发生的累积危险度逐年增加,应建立完善的随访制度。异时性双乳癌的5 年无病生存率与10年总生存率均高于同时性双乳癌。

     

    Abstract: Objective To investigate the clinical and pathological features of primary bilateral breast cancer (BPBC). Methods Medical records of BPBC patients were reviewed from the Tianjin Medical University Cancer Institute and Hospital during 1.1971—11.2011 Data of the synchronous and asynchronous breast cancer were analyzed,including the age of tumor onset,the time interval between two cancer,menstruation,family history,the size of tumor,clinical stage,pathologic characteristics. Results First cancer onset age of the asynchronous breast cancer was earlier than that of synchronous breast cancer(P<0.05).There were no statistical difference between synchronous and asynchronous breast cancer on family history,the size of tumor,clinical stage and pathologic characteristics(P>0.05).The concordance rate of endocrine receptors in synchronous was higher than that in asynchronous breast cancer(P<0.01). Clinical stage,tumor size and the number of involved axillony nodes of the second tumor in both synchronous and asynchronous breast cancer were lower than those of the first tumor.The difference of five-year disease-free survival and ten-year overall survival between synchronous and asynchronous breast cancer had statistically significant(P<0.01). Conclusion The first tumor and the second tumor could been seen as independent disease.Surveillance was necessary to screen the contralateral breast cancer once the primary breast cancer occurred.Five-year disease-free survival and ten-years overall survival in asynchronous breast cancer was higher than those in synchronous breast cancer.

     

  • [1] Robbins GF,Berg JW.Bilateral primary breast cancers.A prospective clinicopathological study [J].Cancer,1964,17(12):1501-27.
    [2] Kan X.Clinical pathology of breast cancer[M].Beijing:Peking Union Medical College Precs,1993:98-102.[阚秀.乳腺癌临床病理学[M].北京:北京医科大学中国协和医科大学联合出版社,1993:98-102.]
    [3] Kheirelseid EA,Jumustafa H,Miller N,et al.Bilateral breast cancer:analysis of incidence,outcome,survival and disease characteristics[J].Breast Cancer Res Treat,2011,126(1):131-40.
    [4] Renz DM,Bottcher J,Baltzer PA,et al.The contralateral synchronous breast carcinoma:acomparison of histology,localization,and magnetic resonance imaging characteristics with theprimary index cancer[J].Breast Cancer Res Treat,2010,120(2):449-59.
    [5] Banelli B,Casciano I,Di Vinci A,et al.Pathological and molecular characteristicsdistinguishing contralateral metastatic from new primary breast cancer[J].Ann Oncol,2010,21(6):1237-42.
    [6] Wolmark N,Fisher B,Wieand HS,et al.The prognostic significance of preoperative carcinoembryonicantiger levels in colorectal cancer.Results from NSABP(National Surgical Adjuvant Breast and BowelProject) clinical trials[J].Ann Surg,1984,199(4):385-82.
    [7] Kuo WH,Yen AM,Lee PH,et al.Cumulative survival in early-onset unilateral and bilateralbreast cancer:an analysis of 1907 Taiwanese women[J].Br J Cancer,2009,100(4):563-70.
    [8] Yu KD,Di GH,Wu J,et al.Clinical and pathologic analysis of primary bilateral breast cancer:areport of 103 cases[J].Zhongguo Ai Zheng Za Zhi,2006,16(5):362-6.[余科达,狄根红,吴炅,等.原发性双侧乳腺癌103例的临床病理分析[J].中国癌症杂志,2006,16(5):362-6.]
    [9] Beckmann KR,Buckingham J,Craft P,et al.Clinical characteristics and outcomes of bilateralbreast cancer in an Australian cohort [J].Breast,2010,20(2):158-64.
    [10] Vuoto HD,Garcia AM,Candas GB,et al.Bilateral breast carcinoma:clinical characteristics andits impact on survival[J].Breast J,2010,16(6):625-32.
    [11] Verkooijen HM,Chatelain V,Fioretta G,et al.Survival after bilateral breast cancer:resultsfrom a population-based study [J].Breast Cancer Res Treat,2007,105(3):347-57.
    [12] Nichol AM,Yerushalmi R,Tyldesley S,et al.A case-match study comparing unilateral withsynchronous bilateral breast cancer outcomes[J].J Clin Oncol,2011,29(36):4763-8.
    [13] Hartman M,Czene K,Reilly M,et al.Incidence and prognosis of synchronous and metachronousbilateral breast cancer[J].J Clin Oncol,2007,25(27):4210-6.
计量
  • 文章访问数:  2941
  • HTML全文浏览量:  25
  • PDF下载量:  934
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-12-18
  • 修回日期:  2012-01-18
  • 刊出日期:  2012-06-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭