Abstract: Objective To estimate treatment regimens，prognosis and skeletal-related events(SREs) for post-menopausal breast cancer(BrCa) patients with bone metastases. Methods One hundred and thirty-six post-menopausal BrCa patients with bone metastases were retrospectively reviewed.Clinical pathologic characteristics were analyzed.Moreover，the incidence of SREs was explored. Results In this cohort，the age of 49 patients was ≥60 years(elderly group)，and 87 patients was below 60 years(younger group).One hundred and four patients received first-line chemotherapy regimens，and 32 patients received first -line endocrine drugs.The proportion of patients with SREs was increased in the elderly group compared with the younger group，20/49(44.9%) vs.30/87(32.2%) respectively without significant difference(P=0.194).Median overall survival time of all patients was 48.0 months(range，39.1~56.9).The overall survival was notably worse in patients with SREs，compared with patients without SREs(P=0.011).No significant difference was noted in median time of overall survival between elderly group and younger group，50.0 months vs.40.0 months(P=0.689).However，compared with the younger group，the median time of PFS in elderly group was longer，17.0 months vs.11.0 months，but without significant difference (P=0.161). Conclusion No significant differences are observed between elderly group and younger group in PFS or OS.The incidence of SREs is slightly increased by age.The overall survival is remarkably worse in postmenopausal BrCa patients with bone metastases and SREs.SREs increase the risk of death.