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绝经后乳腺癌骨转移患者骨相关事件及预后分析

丁晓燕, 樊英, 马飞, 李青, 王佳玉, 袁芃, 张频, 徐兵河

丁晓燕, 樊英, 马飞, 李青, 王佳玉, 袁芃, 张频, 徐兵河. 绝经后乳腺癌骨转移患者骨相关事件及预后分析[J]. 肿瘤防治研究, 2012, 39(06): 627-631. DOI: 10.3971/j.issn.1000-8578.2012.06.004
引用本文: 丁晓燕, 樊英, 马飞, 李青, 王佳玉, 袁芃, 张频, 徐兵河. 绝经后乳腺癌骨转移患者骨相关事件及预后分析[J]. 肿瘤防治研究, 2012, 39(06): 627-631. DOI: 10.3971/j.issn.1000-8578.2012.06.004
Ding Xiaoyan, Fan Ying, Ma Fei, Li Qing, Wang Jiayu, Yuan Peng, Zhang Pin, Xu Binghe. Analyses on Skeletal-related Events and Prognosis of Postmenopausal Breast Cancer Patients with Bone Metastasis[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 627-631. DOI: 10.3971/j.issn.1000-8578.2012.06.004
Citation: Ding Xiaoyan, Fan Ying, Ma Fei, Li Qing, Wang Jiayu, Yuan Peng, Zhang Pin, Xu Binghe. Analyses on Skeletal-related Events and Prognosis of Postmenopausal Breast Cancer Patients with Bone Metastasis[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 627-631. DOI: 10.3971/j.issn.1000-8578.2012.06.004

绝经后乳腺癌骨转移患者骨相关事件及预后分析

详细信息
    作者简介:

    丁晓燕,女,(1981-),博士,住院医师,主要从事乳腺癌内科的研究

    通讯作者:

    徐兵河,E-mail:xubinghe@medmail.com.cn

  • 中图分类号: R737.9

Analyses on Skeletal-related Events and Prognosis of Postmenopausal Breast Cancer Patients with Bone Metastasis

  • 摘要: 目的 探讨绝经后乳腺癌骨转移患者骨相关事件(SREs)、治疗及预后情况。 方法收集我院诊治的136例绝经后乳腺癌骨转移患者的资料,回顾性分析其临床病理特征,探讨骨相关事件、治疗及预后情况。结果患者平均年龄为58.5岁,≥60岁49例(老年组),<60岁87例(年轻组)。其中104例患者接受一线化疗,32例接受一线内分泌治疗。老年组较年轻组总SREs发生率有所增高,分别为44.9%和32.2%,但差异无统计学意义(P=0.194)。合并SREs的与不合并SREs的绝经后患者比较,总生存期(OS)显著缩短(P=0.011)。全组患者中位OS为48.0月,其中,老年组及年轻组中位OS分别为50.0月和40.0月,差异亦无统计学意义(P=0.689)。老年组中位无疾病进展时间(PFS)较年轻组延长,分别为17.0月和11.0月,但差异无统计学意义(P=0.161)。结论年龄是否大于60岁并没有明显影响绝经后乳腺癌骨转移的OS及PFS。绝经后乳腺癌骨转移患者,随年龄增加SREs发生率虽有增加,但差异无统计学意义;合并SREs的绝经后乳腺癌骨转移患者,总生存明显缩短。提示SREs可能增加死亡风险。

     

    Abstract: Objective To estimate treatment regimens,prognosis and skeletal-related events(SREs) for post-menopausal breast cancer(BrCa) patients with bone metastases. Methods One hundred and thirty-six post-menopausal BrCa patients with bone metastases were retrospectively reviewed.Clinical pathologic characteristics were analyzed.Moreover,the incidence of SREs was explored. Results In this cohort,the age of 49 patients was ≥60 years(elderly group),and 87 patients was below 60 years(younger group).One hundred and four patients received first-line chemotherapy regimens,and 32 patients received first -line endocrine drugs.The proportion of patients with SREs was increased in the elderly group compared with the younger group,20/49(44.9%) vs.30/87(32.2%) respectively without significant difference(P=0.194).Median overall survival time of all patients was 48.0 months(range,39.1~56.9).The overall survival was notably worse in patients with SREs,compared with patients without SREs(P=0.011).No significant difference was noted in median time of overall survival between elderly group and younger group,50.0 months vs.40.0 months(P=0.689).However,compared with the younger group,the median time of PFS in elderly group was longer,17.0 months vs.11.0 months,but without significant difference (P=0.161). Conclusion No significant differences are observed between elderly group and younger group in PFS or OS.The incidence of SREs is slightly increased by age.The overall survival is remarkably worse in postmenopausal BrCa patients with bone metastases and SREs.SREs increase the risk of death.

     

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出版历程
  • 收稿日期:  2012-03-25
  • 修回日期:  2012-04-12
  • 刊出日期:  2012-06-24

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