高级搜索

内皮生长因子61基因多态性与肝细胞性肝癌易感性的Meta分析

钟鉴宏, 龚文锋, 黎乐群, 马良, 张宇, 游雪梅

钟鉴宏, 龚文锋, 黎乐群, 马良, 张宇, 游雪梅. 内皮生长因子61基因多态性与肝细胞性肝癌易感性的Meta分析[J]. 肿瘤防治研究, 2012, 39(04): 460-463. DOI: 10.3971/j.issn.1000-8578.2012.04.024
引用本文: 钟鉴宏, 龚文锋, 黎乐群, 马良, 张宇, 游雪梅. 内皮生长因子61基因多态性与肝细胞性肝癌易感性的Meta分析[J]. 肿瘤防治研究, 2012, 39(04): 460-463. DOI: 10.3971/j.issn.1000-8578.2012.04.024
Zhong Jianhong, Gong Wenfeng, Li Lequn, Ma Liang, Zhang Yu, You Xuemei. A Meta-analysis on Relationship between Epidermal Growth Factor 61A/G Polymorphism and Risk of Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 460-463. DOI: 10.3971/j.issn.1000-8578.2012.04.024
Citation: Zhong Jianhong, Gong Wenfeng, Li Lequn, Ma Liang, Zhang Yu, You Xuemei. A Meta-analysis on Relationship between Epidermal Growth Factor 61A/G Polymorphism and Risk of Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 460-463. DOI: 10.3971/j.issn.1000-8578.2012.04.024

内皮生长因子61基因多态性与肝细胞性肝癌易感性的Meta分析

基金项目: 国家自然科学基金资助项目(81160262/H1602)
详细信息
    通讯作者:

    游雪梅,E-mail:you_xuemei@163.com

  • 中图分类号: R735.7;R181.2+3

A Meta-analysis on Relationship between Epidermal Growth Factor 61A/G Polymorphism and Risk of Hepatocellular Carcinoma

  • 摘要: 目的 探讨内皮生长因子(EGF)基因多态性与肝细胞性肝癌(HCC)发病风险的关系。 方法计算机系统检索PubMed、EMABSE 和中国知网等数据库,收集关于EGF 61A/G基因多态性与HCC易感性的病例对照研究,并从纳入文献中提取相关数据进行Meta分析。以病例组和对照组EGF 61A/G基因型分布的比值比(OR)为效应指标,对纳入文献进行异质性检验,应用Stata 10.1软件对各研究原始数据进行合并分析,计算合并OR值及其95%可信区间(CI)。结果共有6篇文献符合纳入标准,累计病例1 304例,对照2 613例。 G/G基因型与G/A+A/A基因型比较的OR值为1.34 (95% CI 1.16~1.54,P<0.001;I2 =36%)。而A/A基因型与G/G+G/A基因型比较的OR值为0.66 (95% CI 0.53~0.83,P<0.001 ;I2 =0%)。结论EGF 61G/G基因型为罹患HCC的易感基因型,而EGF 61A/A基因型则为HCC的保护基因型。

     

    Abstract: Objective To explore the relationship between polymorphism of epidermal growth factor (EGF) 61A/G and the risk of hepatocellular carcinoma(HCC). MethodsElectronic searches of PubMed,EMBASE and CNKI were systematically conducted to select studies.Case-control studies containing available genotype frequencies of EGF 61A/G were chose.Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results Six case-control studies including 1 304 cases and 2 613 controls were performed.Meta-analysis showed significant effect of EGF 61A/G on HCC risk and protection (G/G vs.G/A+A/A:OR=1.34,95%CI=1.16~1.54;A/A vs.G/G+G/A:OR=0.66,95% CI=0.53~0.83). Conclusion The EGF 61G allele is a risk factor of HCC;however,the EGF 61A allele is a protective factor of HCC.

     

  • [1] Urtasun R,Latasa MU,Demartis MI,et al.Connective tissue growth factor autocriny in humanhepatocellular carcinoma:Oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation[J].Hepatology,2011,54(6):2149-2158.
    [2] Kmüves LG,Feren A,Jones AL,et al.Expression of epidermal growth factor and its receptor incirrhotic liver disease[J].J Histochem Cytochem,2000,48(6):821-830.
    [3] Lanuti M,Liu G,Goodwin JM,et al.A functional epidermal growth factor (EGF) polymorphism,EGFserum levels,and esophageal adenocarcinoma risk and outcome[J].Clin Cancer Res,2008,14(10):3216-3222.
    [4] Xu W,Li Y,Wang X,et al.Association between EGF promoter polymorphisms and cancer risk:ameta-analysis[J].Med Oncol,2010,27(4):1389-1397.
    [5] Qi P,Chen YM,Gao CF,et al.Relationship between polymorphism of epidermal growth factor 5'UTRVariant G61A gene and hepatocellular carcinoma in patients with chronic hepatitis B virus infectionin China[J].Zhongguo Sheng Wu Zhi Pin Xue Za Zhi,2008,21(12):1051-1053.[戚鹏,陈岳明,高春芳,等.EGF +61基因多态性与乙型肝炎细胞癌的相关性[J].中国生物制品学杂志,2008,21(12):1051-1053.]
    [6] Abu Dayyeh BK,Yang M,Fuchs BC,et al.A functional polymorphism in the epidermal growth factorgene is associated with risk for hepatocellular carcinoma[J].Gastroenterology,2011,141(1):141-149.
    [7] Tanabe KK,Lemoine A,Finkelstein DM,et al.Epidermal growth factor gene functionalpolymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis[J].JAMA,2008,299(1):53-60.
    [8] Li Y,Xie Q,Lu F,et al.Association between epidermal growth factor 61A/G polymorphism andhepatocellular carcinoma susceptibility in Chinese patients[J].Liver Int,2010,30(1):112-118.
    [9] Qi P,Wang H,Chen YM,et al.No association of EGF 5'UTR variant A61G and hepatocellularcarcinoma in Chinese patients with chronic hepatitis B virus infection[J].Pathology,2009,41(6):555-560.
    [10] Chen K,Wei Y,Yang H,et al.Epidermal growth factor +61 G/A polymorphism and the risk ofhepatocellular carcinoma in a Chinese population[J].Genet Test Mol Biomarkers,2011,15(4):251-255.
    [11] Wang HX,Xie WM,Zhou GQ.Epidermal growth factor gene polymorphism associated withsusceptibility to hepatocellular carcinoma[D].Guangxi Medical University,2009.[王洪学,谢伟敏,周钢桥.表皮生长因子基因多态性与肝癌的遗传关联研究[D].广西:广西医科大学,2009.]
    [12] Casula M,Alaibac M,Pizzichetta MA,et al.Role of the EGF +61A>G polymorphism in melanomapathogenesis:an experience on a large series of Italian cases and controls[J].BMC Dermatol,2009,9:7.
    [13] Llovet JM,Bruix J.Molecular targeted therapies in hepatocellular carcinoma[J].Hepatology,2008,48(4):1312-1327.
    [14] Ji H,Li D,Chen L,et al.The impact of human EGFR kinase domain mutations onlungtumorigenesis and in vivo sensitivity to EGFR-targeted therapies[J].Cancer Cell,2006,9(6):485-495.
    [15] Ciardiello F,Tortora G.EGFR antagonists in cancer treatment[J].N Engl J Med,2008,358(11):1160-1174.
计量
  • 文章访问数:  2392
  • HTML全文浏览量:  17
  • PDF下载量:  639
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-10-26
  • 修回日期:  2012-02-01
  • 刊出日期:  2012-04-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭