COX-2 -1195G>A多态与结直肠癌易感性关系的Meta分析

姚志文; 赵振龙; 姜玉梅; 米颖; 古妙宁

doi:10.3971/j.issn.1000-8578.2012.02.024

COX-2 -1195G>A多态与结直肠癌易感性关系的Meta分析

510515广州，南方医科大学南方医院麻醉科

详细信息

中图分类号: R735.3⁺5
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出版历程
- 收稿日期: 2011-06-14
- 修回日期: 2011-11-02
- 刊出日期: 2012-02-24

Meta-analysis for Association between Polymorphism of COX-2 -1195G>A and Colorectal Cancer Susceptibility

Department of Anesthesiology，Nanfang Hospital Affiliated to Southern Medical University，Guangzhou 510515，China

摘要

摘要: 目的综合评价COX-2 -1195G>A多态与结直肠癌易感性的关系。方法检索PUBMED和中国生物医学文献数据库CBM数据库，查找关于COX-2 -1195G>A多态与结直肠癌易感性的关系的病例对照研究，并用Meta分析的方法合并COX-2 -1195G>A 多态与结直肠癌易感性的关系的OR值(odds ratio)，同时也进行了亚组分析、敏感度分析和文献的发表偏倚检验。结果本次Meta分析共纳入6篇文献，累计病例数2854，对照数4250，显性模型下AA+AG基因型相对于GG基因型的OR值为1.29(95%CI:1.09～1.54)，差异具有统计学意义。结论COX-2 -1195G>A多态与结直肠癌易感性在显性模型下具有相关性。
- COX-2 -1195G>A /
- 多态 /
- 结直肠癌 /
- Meta分析
Abstract: Objective To evaluate the association between COX-2 -1195G>A polymorphism and colorectal cancer susceptibility. Methods Literatures on the case-control studies on the association between COX-2 -1195G>A and colorectal cancer susceptibility，were collected from PUBMED and CBM database and then pooled odds ratio(OR) was assessed by Meta-analysis.We also performed subgroup analysis and sensitivity analysis and publication bias test. Results Six studies with 2854 cases and 4250 controls were enrolled in this Meta-analysis.The pooled OR of AA+AG genotype compared to GG genotype under dominant model was 1.29(95%CI:1.09~1.54) with significant difference. Conclusion The COX-2 -1195G>A polymorphism was significantly association with the colorectal cancer susceptibility under the dominant model.
- COX-2 -1195G>A /
- Polymorphism /
- Colorectal cancer /
- Meta-analysis