Basal-like型乳腺癌临床特征与生存分析
Clinical Characteristics and Survival Analysis of Basal-like Breast Cancer Patients
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摘要: 目的 分析Basal-like型乳腺癌所占比例、临床特征以及生存情况，为Basal-like型乳腺癌临床诊治提供参考依据。方法 回顾性分析我院经手术治疗、资料完整、经病理确诊的女性乳腺癌患者171例。Basal-like型乳腺癌的判定采用Nielsen标准。比较Basal-like型乳腺癌与非Basal-like型乳腺癌的临床病理特征、复发转移及生存情况。结果 Basal-like型乳腺癌26例，占15.3%。Basal-like型乳腺癌具有组织学分级高（Basal-like型与非Basal-like型乳腺癌组织学分级Ⅲ级的比例分别为：69.23%和30.34%，P＜0.001），淋巴结转移阳性率低（34.62%和58.62%，P=0.023），淋巴结转移率低（41.38%和65.38%，P=0.038）的特点。与非Basal-like型乳腺癌相比，Basal-like型乳腺癌肺转移发生率较高（15.38%和3.45%，P=0.012）。Basal-like型乳腺癌和非Basal-like型乳腺癌的5年生存率分别为70.3%和87.9%（P=0.042），5年无病生存率分别为59.5%和80.3%（P=0.013）。结论本组患者并没有发现回、汉族患者Basal-like型乳腺癌的发病率差别。本组Basal-like型乳腺癌患者具有组织学分级高、淋巴结转移阳性率低、淋巴结转移率低、易于发生肺转移和预后较差的特点。Abstract: Objective To analyses the prevalence the clinical characteristics and survival time of Hui and Han patients with basal-like breast cancer in our hospital. Methods One hundred seventy one female breast cancer patients，were collected into this retrospective study.Basal-like breast cancer was defined by Nieslsen's method.Clinical characteristics，recurrence and metastatic time，and overall survival time were compared between basal-like and non- basal-like groups. Results basal-like breast cancer patients accounted for 15.3%(26/171).Compared with non- basal-like group，basal-like breast cancer had higher histologic tumor grade(69.23% vs.30.34%，P<0.001)，less metastatic lymph nodes(34.62% vs. 58.62%，P=0.023)，lower lymph nodes metastatic ratio(41.38% vs.65.38%，P=0.038).Basal-like breast cancer had a propensity for lung metastases.The five-year overall survival(OS) rates of basal-like and non- basal-like group were 70.3% and 87.9%，respectively.The five-year disease free survival(DFS) rates of two groups were 59.5% and 80.3%，respectively. Conclusion The prevalence of basal-like breast cancer was not markdedly different between Hui and Hanrace.Basal-like breast cancer had special clinical characteristics and poor survival.
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