三阴性乳腺癌的预后与上皮间叶转化的相关性

龚益平; 漆楚波; 王明伟; 陈创; 赵德绵; 许娟; 邵军; 程洪涛; 夏和顺

doi:10.3971/j.issn.1000-8578.2012.02.014

三阴性乳腺癌的预后与上皮间叶转化的相关性

Prognosis of Triple-negative Breast Cancer and Its Relevance to Epithelial-mesenchymal Transitions

摘要

摘要: 目的探讨三阴性乳腺癌的预后及与上皮间叶转化的关系。方法乳腺癌患者240例，根据ER、PR、Her-2的检测结果分为三组：三阴性组、受体阳性组和Her-2阳性组。原发灶石蜡标本制作组织芯片，免疫组织化学检测Vimentin的表达，比较三组的预后及Vimentin的表达差异。结果三阴性组的总生存及5年生存率均比受体阳性组差，和Her-2阳性组相比，差异无统计学意义。而三阴组的Vimentin阳性表达率明显高于受体阳性组或Her-2阳性组。结论三阴性乳腺癌的预后与上皮间叶转化有关。

Abstract: Objective To investigate the prognosis of triple-negative breast cancer and its relevance to epithelial-mesenchymal transition(EMT). Methods Two hundred and forty patients of breast cancer were classified into 3 groups，triple-negative group，receptor positive group and Her-2 positive group，according to the expression of estrogen receptor and progesterone receptor as well as Her-2 protein.Paraffin-embedded specimens of the primary tumors were collected and tissue micro-array blocks were constructed.Vimentin expressions were detected by imunohistochemistry.The prognosis and vimentin expression among the 3 groups were analyzed. Results The overall survival and the 5 year survival rate of triple-negative group were significantly decreased compared to receptor positive group，but were not statistically different from those of Her-2 group. Conclusion The poor prognosis of triple-negative breast cancer was associated with EMT.

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