Abstract: Objective To review the distribution of clinical research essays on breast cancer prognostic genes over the past decade and provide reference for further study. Methods We searched for essays in Embase,Pubmed and Biosis Preview database from January 2001 to December 2010.In this bibliometric analysis,all essays were managed with Endnote X3;Data were processed with Excel 2007. Results Eight hundred and seventy-six essays were included and the numbers of which grew slowly in the first five years but rapidly in the second one. The essays included were mainly on singular gene,specially on gene ErbB-2（157 essays）.Though essays on multi-gene model were less than those on singular gene,they gradually increased with the year specially the essays on MammaPrint and Oncotype DX.The country,journal,institution and author with the largest number of essays published was “United States”,Breast Cancer Research and Treatment,“Netherlands Cancer Institute” and “Bieche I”,respectively. Conclusion Worldwide researchers pay more and more attention to breast cancer prognostic genes,and searching for its sensitive and specific genes and multi-gene profiles will be an important target for the future study.