Abstract: Objective To investigate three negative breast cancer and basal-like breast cancer patients with clinical pathologic characteristics and prognosis of relevancy. Methods All of the 69 patients were proved to be triple-negative by immunohistochemical screening or FISH testing.Immunohistochemical staining was performed for the CK5/6,CK14,and CK17 basal markers in 69 patients for the purpose of classifying as basal or non-basal phenotype,and classify the TNBC on the basis of being positive or negative for lymph node metastasis,then the clinicopathological features and outcome of the patients was analyzed. Results Forty patients (58.0%) were the BLBC.In the node-negative group,compared with the NBP,the BP were significantly larger in tumor size,and were higher in incidence of EGFR-positive,incidence of vascular invasion,grade of histology and nuclear,and showed a higher incidence of recurrence and distant metastasis. Conclusion It is required to test for basal markers′ expression and classify TNBC,this will aid in deciding the therapeutic strategy and prognosis for triple-negative breast cancer.