Abstract: Objective To assess the significance of Moesin and E-cadherin in invasion and metastasis of papillary thyroid carcinoma(PTC). Methods The expressions of Moesin and E-cadherin in 81 cases of PTC and normal thyroid tissues adjacent to cancer were analyzed by immunohistochemical staining.The correlation between these 2 factors(Moesin,E-cadherin)and clinical features of PTC such as gender，age，tumor size，invasion and lymph node metastasis were studied. Results The rates of immuno-positive staining of Moesin and E-cadherin in PTC were significantly higher than that in the normal thyroid tissues adjacent to cancer (P<0.01).The positive expression rates of Moesin in PTC with age≥45 years，local invasion，lymph node metastasis and in stage Ⅲ～Ⅳ was higher than PTC with age<45 years， without local invasion，without metastasis and in stage Ⅰ～Ⅱ. There was significant difference,respectively(P<0.01).The positive expression rates of E-cadherin in PTC with age≥45 years，local invasion，lymph node metastasis and in stage Ⅲ～Ⅳ was lower than PTC with age <45 years， without local invasion，without metastasis and in stage Ⅰ～Ⅱ.There was significant difference,respectively(P<0.01).There was correlation between the expressions of Moesin and E-cadherin in PTC(r =-0.494，P<0.01). Conclusion The high expressions of Moesin and the low expression of E-cadherin were related to invasion and metastasis of PTC.And the 2 factors have cooperative.