Abstract: ObjectiveWe studied the clinical characters of 357 cases with cutaneous malignant melanoma in our center to identify the epidemiological characteristics and prognostic factors of malignant melanoma in China. MethodsClinical data of 357 cases with cutaneous malignant melanoma in our center were analyzed by SPSS11.5 software and life-table method of survival analysis and Cox regression statistical multi-factor analysis were done. ResultsThe median survival time in stageⅠ patients was more than 144.0 months,and in stage Ⅱ, Ⅲ and Ⅳ was 95.7, 132.0 and 26.8 months, respectively. Two hundred and eighteen cases (61.1%) were of acral malignant melanoma. Multivariate survival analysis showed that the staging at the first examination and ulceration were independent prognostic factors affecting survival. ConclusionThe incidence of acral malignant melanoma was the highest. Primary tumor in the extremities was the most common. The prognosis was closely related to the staging and ulceration.