Abstract: ObjectiveTo reveal the relationship between female lung cancer in Xuanwei region and 8-hydroxy-2-deoxyguonosine(8-OHdG). Methods 8-OHdG Content in urine was measured using the 8-OHdG ELISA (enzymelinked immunosorbent assay).The urine creatinine was measured using picric acid.The final results of 8-OHdG content was expressed with ng/mg creatinine. Results (1)8-OHdG were expressed in the urine samples of all patients, the content of 8-OHdG in urine of lung cancer patients was much higher than that of benign pulmonary diseases patients (P<0.01).(2)The content of 8-OHdG in urine of female lung cancer patients was higher than that of male lung cancer patients in Xuanwei region in Xuanwei region and female lung cancer patients in other regions(P<0.01).(3)The content of 8-OHdG in urine of female benign pulmonary diseases patients was much higher than that of male benign pulmonary diseases patients and female benign pulmonary diseases patients in other regions (P<0.01). Conclusion The 8-OHdG produced by DNA oxidative damage maybe play an important role in the occurrence and development of lung cancer.The oxidative damage of female in Xuanwei region is suffered higher than male in Xuanwei region and female in other regions.This may be one risk factor of high incidence of female lung cancer in other regions.