STAT5和c-myc在大肠癌中的表达及意义

吴民华; 陈小毅; 梁艳清

doi:10.3971/j.issn.1000-8578.2011.07.022

STAT5和c-myc在大肠癌中的表达及意义

Expression of STAT5 and c-myc in Colorectal Carcinoma and Its Clinical Significance

摘要

摘要: 目的探讨大肠癌中STAT5和c-myc蛋白表达与肿瘤病理特征的关系及两者的相关性。方法采用免疫组织化学SP法检测56例大肠癌组织STAT5和c-myc蛋白的表达，同时选取16例大肠腺瘤组织作对照。结果STAT5在结肠癌组织中的阳性表达率（34/56，60.7%）明显高于大肠腺瘤组织（3/16，18.8%），P<0.01。STAT5表达与肿瘤Dukes临床分期及淋巴结转移均呈正相关（P<0.05）。c-myc在结肠癌组织中的阳性表达率（35/56，62.5%）明显高于大肠腺瘤组织（4/16，25.0%），P<0.01。c-myc表达与肿瘤分化程度、Dukes临床分期及淋巴结转移等均无明显相关（P>0.05）。STAT5和c-myc在大肠癌中表达呈正相关(r=0.359，P<0.01)。结论STAT5和c-myc在大肠癌的发生发展中起重要作用；STAT5检测可作为判断大肠癌恶性程度的指标；大肠癌中c-myc表达可能受STAT5调控。

Abstract: ObjectiveTo explore the expression of signal transducer and activator of transcription 5(STAT5) and c-myc in colorectal carcinoma(CRC) tissues and its correlation with clinicopathological features. MethodsProtein levels of STAT5 and c-myc in CRC(56 cases) and colorectal adenoma(16 cases) tissues were detected by immunohistochemistry method. ResultsThe positive rate of STAT5 in CRC (34/56, 60.7%) was higher than that in colorectal adenoma(3/16, 18.8%), P<0.01. STAT5 expression was related to Dukes stage and lymph node metastasis(P<0.05). The positive rate of c-myc in CRC (35/56, 62.5%) was also higher than that in colorectal adenoma(4/16, 25.0%), P<0.01. However, c-myc expression was not associated with differentiation degree, Dukes stage and lymph node metastasis(P>0.05). There was a positive correlation between the expression of STAT5 and c-myc in CRC (r=0.359，P<0.01). Conclusion STAT5 and c-myc play a role in the oncogenesis and development of CRC. STAT5 can be used to evaluate the biological behavior of CRC. The expression of c-myc is probably regulated by STAT5 in CRC.

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