整合素α5β1和E-选择素蛋白在结直肠腺癌中的表达及意义
Expression of Integrinα5β1 and E-selectin in Colorectal Adenocarcinoma and Its Clinical Implication
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摘要: 目的探讨整合素α5β1（integrin α5β1）和E-选择素（E-selectin）蛋白在结直肠腺癌中的表达及其临床病理意义。方法采用免疫组织化学PV方法检测Integrin α5β1 和E-selectin蛋白在80例结直肠腺癌组织、15例结直肠腺瘤、10例癌旁正常肠组织中的表达情况。结果80例结直肠腺癌组织中Integrin α5β1和E-selectin蛋白表达阳性率分别为67.50%和58.75%，其表达均高于相应的结直肠腺瘤及癌旁组织(P<0.05)。低分化腺癌组织中Integrin α5β1与E-selectin蛋白表达均高于高、中分化腺癌组织(P<0.05)，且两者表达均与癌组织浸润深度、Dukes分期及淋巴结转移有关（P<0.05）。Integrin α5β1与E-selectin蛋白表达之间存在明显相关性(rs=0.264, P<0.05)。结论Integrin α5β1与E-selectin蛋白在结直肠腺癌中高表达,两者可能共同参与了结直肠腺癌的浸润转移过程。Abstract: ObjectiveTo approach the expression and clinicopathological significance of integrin α5β1 and E- selectin proteins in colorectal adenocarcinoma. MethodsUsing immunohistochemistry PV method to detect the expression of integrin α5β1 and E-selectin proteins in 80 colorectal adenocarcinoma,15 colorectal adenoma and 10 mucosae adjacent to carcinoma. ResultsThe positive rates of integrin α5β1 and E-selectin proteins were 67.50% and 58.75%,respectively in 80 cases of colorectal adenocarcinoma. The expression of integrin α5 β1 and E-selectin proteins were remarkably higher in 80 cases of colorectal adenocarcinoma than that in control specimens（P<0.05）.The expression of integrin α5β1 and E-selectin proteins in poor differentiated tissues was higher than that in well-moderate differentiated tissues（P<0.05）, Integrin α5β1 and E-selectin proteins expression was correlated with the infiltration depth and the different Dukes stage and lymph node metastasis of colorectal adenocarcinoma(P<0.05). The expression of integrin α5β1 was positively correlated with E- selectin（rs=0.264, P<0.05). ConclusionThe high expression of integrin α5β1 and E-selectin proteins in colorectal adenocarcinoma suggests that they might play synergetic roles in invasion and metastasis of the colorectal adenocarcinoma.
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