8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险的Meta分析

Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men　

摘要: 目的运用Meta分析的方法探讨8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险的关系。方法检索在2009年底前在PubMed及中国期刊全文数据库发表的中英文文献。用RevMan4.2软件进行荟萃分析，评估异质性和发表偏倚。结果4篇文献共3组不同种族人群纳入分析，前列腺癌组1 391例，对照组1 274例。前列腺癌组和对照组rs1447295A/C多态性现象中AA+CA基因型频率与常见的纯合子CC基因型频率的合并比值比（OR）值为1.50,95%可信区间值为1.28~1.77，Z=4.92，P<0.00001。结论8q24染色体rs1447295A/C多态性与亚洲人群前列腺癌发病风险显著相关。

Abstract: ObjectiveTo investigate the association of the rs1447295 locus polymorphism in the 8q24 chromosome and the risk of prostate cancer by means of Meta-analysis. MethodsAn electric search was performed in PubMed and CNKI database at the end of Dec 2009.All analyses were conducted with Review Manager Version 4.2 software. Results4 literatures with 3 different ethnic groups were studied, totally including the PCa(Prostate Cancer) group(1 391 cases) and the normal control(1 274 cases).The summary OR for studies with frequency of AA+CA genotype at rs1447295 locus in the 8q24 was 1.50(95%CI: 1.28~1.77，Z=4.92，P<0.00001). ConclusionThe meta-analysis suggests that the polymorphism at the rs1447295 locus of 8q24 might be a genetic risky factor for prostate cancer in Asian men.