核PTEN在胃癌中的表达及其意义

Expression and Prognostic Significance of Nuclear PTEN in Gastric Cancer

摘要: 目的探讨定位于核的PTEN在胃癌组织中的表达及与临床病理学特征及预后的关系。方法应用组织芯片、免疫组织化学技术检测85例胃癌组织中核PTEN蛋白表达水平并随访，分析其与临床病理学特征相互关系及其预后价值。结果核PTEN在61例（71.76%）胃癌组织中过表达，核PTEN过表达与预后有显著相关性（P<0.05），与胃癌患者Lauren's分型和淋巴结转移密切相关（P＝0.011，P＝0.023）。结论胃癌组织中存在核PTEN低表达，核PTEN与胃癌的预后密切相关，是潜在的肿瘤治疗靶点。

Abstract: ObjectiveTo evaluate the expression of nuclear PTEN in gastric cancer tissues and identify whether nuclear PTEN was a prognostic factor through analysis for the correlation with clinipathological features. MethodsThe expression of nuclear PTEN proteins was detected by tissue array and immunohistochemistry in 85 cases of gastric cancer . The relationships between nuclear PTEN expression and their clinipathological features were evaluated. ResultsThe over expression rate of nuclear PTEN in gastric cancer was 71.76% (61/85). A significant positive correlation was observed between nuclear PTEN and prognosis (P<0.05). Nuclear PTEN was significantly related to Lauren's classification (P=0.011) and lymph node metastasis (P=0.023). ConclusionNuclear PTEN was over expressed and might be a prognostic factor and a potential therapy target in gastric cancer.