Abstract: ObjectiveTo investigate the therapeutic efficacy of ⁹⁹Tc-MDP combining with ⁸⁹Sr in alleviating pain of patients with osseous metastasis. Methods 89Sr 3mci was intravenously injected into 120 patients with osseous metastasis, after a week, 99Tc-MDP, 22mg/d, was intravenously injected for 10 days.One course of treatment was one month and was carried on 3 to 6 months；⁸⁹Sr was used in every 3 to 4 months, three times at most. Results The pain was significant relieved in 107 patients, relieved in 8 patients,and inefficient in 5 patients.The effective power was 96% (relieve in 2 or 3 weeks)；The time extended more than a year and a half.Myelosuppression was occured in few patient;Some patients with destruction of bone were obviously recovered. Conclusion There are conspicuous effect of 99Tc-MDP combining with ⁸⁹Sr in therapying patients with osseous metastasis and conspicuous recovery for destruction of bone induced by osseous metastasis；Patients with osseous metastasis should be treated with ⁹⁹Tc-MDP combining with 89Sr at an early date.