Abstract: ObjectiveTo explore the circumstance of hTERC gene amplification in the differ cervix disease and the forecasting significance between hTERC gene amplification and developmental tendency of cervix. Methods Using fluorescence microscope to observe the crossing effection of centromeric probe for 3 chromosome and the probe of hTERC gene. The circumstance of hTERC gene amplification is detected in the differ cervix disease.Meanwhile,the cases which have hTERC gene amplification are followed up. Results Amplification of hTERC gene is enhanced along with the development of cervix disease which has statistical significance. Conclusion There is close correlation between the hTERC gene amplification and the development of cervix disease,Using FISH to detect hTERC gene amplification may be the dependable means to forecast the developmental tendency of cervix disease.