微波消融术对原发性肝癌肝纤维化指标的影响

Percutaneous Microwave Coagultion Therapy Influence on Hepatofibrosis of Primary Hepatocellular Carcinoma Serum

摘要: 目的探讨微波消融（PMCT）治疗中晚期肝癌对肝纤维化五项指标的影响。方法49例微波消融的原发性肝癌患者，观察治疗前后血清HA、LN、PC-Ⅲ、Ⅳ-C、TGF-β1五项肝纤维化指标水平。结果PMCT治疗后与PMCT治疗前相比，HA、LN、PC-Ⅲ、Ⅳ-C差异无统计学意义，TGF-β1每次均有下降（P＜0.05）。结论 PMCT治疗原发性肝癌对HA、LN、PC-Ⅲ、Ⅳ-C无影响，且对肝纤维化有一定抑制作用。

Abstract: ObjectiveTo study the influence of the percutaneous microwave coagultion therapy (PMCT) on five hepatofibrosis indexes of middle and advanced hepatocellular carcinoma. MethodsForty-nine cases of primary hepatocellular carcinoma(massive type or nodular type) who had received curation of PMCT，hepatofibrosis index levels of serum HA、LN、PC Ⅲ、IV-C、TGF-β1 were observed before and after therapy. ResultsNo significance difference was observed in relation to HA、LN、PC Ⅲ、IV-C of patients before and after every duration of PMCT.But the TGF-β1 was continuously reduced(P＜0.05). Conclusion The HA、LN、PC-Ⅲ、Ⅳ-C were not significantly changed after PMCT, but the TGF-β1 was continuously reduced.