Abstract: ObjectiveTo analyze the prognosis factors affecting long-term results in elderly nasopharyngeal carcinoma. MethodsOne hundred and seventy-one nasopharyngeal carcinoma with clinical data with age equal to or greater than 60 years were observed at our hospital. Prognosis factors were studied by univariate and multivariate analyses for survival. ResultsThe 1-year, 3-year, 5-year overall survival rates and cancer-specific survival rates of the 171 elderly nasopharyngeal carcinoma patients were 78%, 55%,40% and 84%, 63%, 52%, respectively. Gender, clinical stage, T stage, N stage, violations of the skull base bone, cranial nerve injury and radiotherapy interruption days were significant prognostic factors of survival rates by single-factor analysis (P<0.05).Multivariate analysis showed that clinical stage and radiotherapy interruption days were also independent predictors. ConclusionClinical stage and radiotherapy interruption days can affect the prognosis of aged nasopharyngeal carcinoma patients. Elderly patients have a great risk of death from non-malignant diseases.