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血红蛋白水平对宫颈癌患者放射治疗疗效的 影响

Impact of Hemoglobin(Hgb) Level on Therapeutic Effect of Radiotherapy in Cervical Cancer Patients

  • 摘要: 目的 回顾性分析宫颈癌患者血红蛋白(Hgb)水平对根治性放射治疗预后的影响。方法 经病理诊断证实宫颈癌患者862例行根治性放射治疗,外照射采用8MV-X射线前后二野或盒式四野照射方法,剂量(30~36)Gy后行宫旁淋巴引流区推量照射(18~24)Gy;宫颈腔内近距离放疗(6~7)Gy/次×(5~6)次;放疗总剂量:A点(60~70)Gy,B点(50~55)Gy。放疗中对症止血治疗。结果 不同程度贫血对宫颈癌放疗的局部控制率和远期疗效有明显影响。结论 Hgb浓度影响宫颈癌的局部控制率和远期生存率,放疗前尽量提高患者Hgb水平至100g/L以上。

     

    Abstract: Objective To investigate the impact of the cervical cancer patients- hemoglobin(Hgb) level on the prognosis of radical radiotherapy by retrospective analysis. Methods Eight hundred and sixty-two pathologically verified patients with cervical cancer were treated with radical radiotherapy,8MV-X ray was used for external radiation with a dose of (30~36)Gy by anterior-posterior two-fields or boxlike four-fields radiation technique,and then the lymphatic drainage area beside pelvic was added a dose of (18~24)Gy.Meanwhile,the patients were also treated with after loading radiotherapy with the dose of (6~7)Gy/fraction×5-6fraction.The total dose of A point is (60~70)Gy,B point is (50~55)Gy.During the radiotherapy,we gave the patients symptomatic treatment. Results The anemias in different degree have significant impact on the local control rate and long-term survival rate of the cervical cancer patients who were treated with radiotherapy. Conclusion The concentration of Hgb influences the local control rate and long-term survival rate of cervical cancer patients.We should elevate the patients' Hgb level higher than 100g/L before radiation.

     

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