Abstract: Objective To investigate the therapeutic effect of Ar-He cryoablation treatment on implanted VX2 liver tumor in rabbit model. Methods Thirty rabbits with VX2 liver carcinoma were divided into group A，B and C randomly (each group n=10)，they were treated by sham operation，hepatic resection or cryotherapy 14 days after implantation，respectively. Nonenhanced and dynamic contrast material-enhanced computed tomography(CT) in 14 and 28 days after treatment.The CT manifestations of VX2 carcinoma in three groups were observed and the metastatic rate of three groups within liver was compared. Results In the 14 days after cryoablation，all cryolesions exhibited low density，no enhancement，accompanied by ring enhancement in margin.In the 28 days after cryoablation，plain scan showed low density in cryolesions in group C，in which some lesions'margins without ring enhancement but others revealed ring enhancement with extension，which pathologically demonstrated residual tumor.The liver metastatic rate in C group was significantly lower compared with that in A group (P<0.05) in the 35 days after treatment. Conclusion Pathology demonstrated that VX2 carcinoma was completed destroyed and liver metastasis was reduced after Argon-Helium cryoablation.CT is valuable in assessing the therapeutic effect of Argon-Helium cryoablation for liver cancer.